Human Gene SSTR2 (ENST00000357585.4)
  Description: Homo sapiens somatostatin receptor 2 (SSTR2), mRNA. (from RefSeq NM_001050)
RefSeq Summary (NM_001050): Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000357585.4
Gencode Gene: ENSG00000180616.9
Transcript (Including UTRs)
   Position: hg38 chr17:73,165,010-73,176,633 Size: 11,624 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr17:73,169,320-73,170,429 Size: 1,110 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:73,165,010-73,176,633)mRNA (may differ from genome)Protein (369 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
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HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: SSR2_HUMAN
DESCRIPTION: RecName: Full=Somatostatin receptor type 2; Short=SS-2-R; Short=SS2-R; Short=SS2R; AltName: Full=SRIF-1;
FUNCTION: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.
SUBUNIT: The C-terminus interacts with SHANK1 PDZ domain.
INTERACTION: P32745:SSTR3; NbExp=3; IntAct=EBI-6266898, EBI-6266935;
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Cerebrum and kidney. In lesser amounts in jejunum, colon and liver.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: SSTR2
Diseases sorted by gene-association score: pancreatic endocrine carcinoma (22), type c thymoma (12), neuroendocrine tumor (11), pituitary adenoma (10), acromegaly (9), olfactory neuroblastoma (9), pituitary adenoma, prolactin-secreting (8), hormone producing pituitary cancer (7), medullary thyroid carcinoma, familial (7), mixed ductal-endocrine carcinoma (6), pituitary carcinoma (6), carcinoid tumors, intestinal (6), pancreatic cancer (5), skull base meningioma (5), adenoma (4), pituitary adenoma, acth-secreting (4), medulloblastoma (2), meningioma, familial (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.85 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 107.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -173.40371-0.467 Picture PostScript Text
3' UTR -2142.706204-0.345 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000586 - Somatstn_rcpt
IPR002074 - Somatstn_rcpt_2

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P30874
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004994 somatostatin receptor activity
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0042923 neuropeptide binding

Biological Process:
GO:0006937 regulation of muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007283 spermatogenesis
GO:0008285 negative regulation of cell proliferation
GO:0021549 cerebellum development
GO:0030432 peristalsis
GO:0030900 forebrain development
GO:0038170 somatostatin signaling pathway
GO:0042594 response to starvation
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071392 cellular response to estradiol stimulus

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection


-  Descriptions from all associated GenBank mRNAs
  AK290745 - Homo sapiens cDNA FLJ78209 complete cds, highly similar to Homo sapiens somatostatin receptor 2, mRNA.
BC019610 - Homo sapiens somatostatin receptor 2, mRNA (cDNA clone MGC:24950 IMAGE:3875163), complete cds.
AK313866 - Homo sapiens cDNA, FLJ94499, highly similar to Homo sapiens somatostatin receptor 2 (SSTR2), mRNA.
JD023320 - Sequence 4344 from Patent EP1572962.
JD336494 - Sequence 317518 from Patent EP1572962.
JD031204 - Sequence 12228 from Patent EP1572962.
JD458888 - Sequence 439912 from Patent EP1572962.
JD281320 - Sequence 262344 from Patent EP1572962.
JD491814 - Sequence 472838 from Patent EP1572962.
JD521756 - Sequence 502780 from Patent EP1572962.
JD426000 - Sequence 407024 from Patent EP1572962.
AB385064 - Synthetic construct DNA, clone: pF1KB5208, Homo sapiens SSTR2 gene for somatostatin receptor type 2, complete cds, without stop codon, in Flexi system.
DQ891280 - Synthetic construct clone IMAGE:100003910; FLH170696.01X; RZPDo839A07100D somatostatin receptor 2 (SSTR2) gene, encodes complete protein.
BC095495 - Homo sapiens somatostatin receptor 2, mRNA (cDNA clone MGC:111698 IMAGE:6971895), complete cds.
CU676452 - Synthetic construct Homo sapiens gateway clone IMAGE:100019106 5' read SSTR2 mRNA.
KJ892208 - Synthetic construct Homo sapiens clone ccsbBroadEn_01602 SSTR2 gene, encodes complete protein.
E11322 - Human cDNA encoding somatostatin receptor subtype 2.
BT019926 - Homo sapiens somatostatin receptor 2 mRNA, complete cds.
BC009522 - Homo sapiens, clone IMAGE:3354783, mRNA, partial cds.
BC000256 - Homo sapiens, Similar to somatostatin receptor 2, clone IMAGE:3357456, mRNA, partial cds.
JD450578 - Sequence 431602 from Patent EP1572962.
JD464440 - Sequence 445464 from Patent EP1572962.
JD239690 - Sequence 220714 from Patent EP1572962.
AK093950 - Homo sapiens cDNA FLJ36631 fis, clone TRACH2018345.
JD144696 - Sequence 125720 from Patent EP1572962.
JD543948 - Sequence 524972 from Patent EP1572962.
JD543949 - Sequence 524973 from Patent EP1572962.
JD543953 - Sequence 524977 from Patent EP1572962.
JD543950 - Sequence 524974 from Patent EP1572962.
JD543952 - Sequence 524976 from Patent EP1572962.
JD543951 - Sequence 524975 from Patent EP1572962.
JD220435 - Sequence 201459 from Patent EP1572962.
JD411826 - Sequence 392850 from Patent EP1572962.
JD105620 - Sequence 86644 from Patent EP1572962.
JD161909 - Sequence 142933 from Patent EP1572962.
JD548178 - Sequence 529202 from Patent EP1572962.
JD548179 - Sequence 529203 from Patent EP1572962.
JD259123 - Sequence 240147 from Patent EP1572962.
JD417785 - Sequence 398809 from Patent EP1572962.
JD545190 - Sequence 526214 from Patent EP1572962.
JD545189 - Sequence 526213 from Patent EP1572962.
JD283340 - Sequence 264364 from Patent EP1572962.
JD152433 - Sequence 133457 from Patent EP1572962.
JD408191 - Sequence 389215 from Patent EP1572962.
JD408192 - Sequence 389216 from Patent EP1572962.
JD401646 - Sequence 382670 from Patent EP1572962.
JD401364 - Sequence 382388 from Patent EP1572962.
JD112361 - Sequence 93385 from Patent EP1572962.
JD144639 - Sequence 125663 from Patent EP1572962.
JD144640 - Sequence 125664 from Patent EP1572962.
JD497679 - Sequence 478703 from Patent EP1572962.
JD212463 - Sequence 193487 from Patent EP1572962.
JD412869 - Sequence 393893 from Patent EP1572962.
JD512857 - Sequence 493881 from Patent EP1572962.
AF131798 - Homo sapiens clone 25119 mRNA sequence.
AK091326 - Homo sapiens cDNA FLJ34007 fis, clone FCBBF1000349.
JD476917 - Sequence 457941 from Patent EP1572962.
JD397544 - Sequence 378568 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P30874 (Reactome details) participates in the following event(s):

R-HSA-374758 Somatostatin receptors bind somatostatin and cortistatin
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K3Y0, ENST00000357585.1, ENST00000357585.2, ENST00000357585.3, NM_001050, P30874, Q4VBP0, Q96GE0, Q96TF2, Q9BWH1, SSR2_HUMAN, uc002jje.1, uc002jje.2, uc002jje.3, uc002jje.4, uc002jje.5
UCSC ID: ENST00000357585.4
RefSeq Accession: NM_001050
Protein: P30874 (aka SSR2_HUMAN)
CCDS: CCDS11691.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.