Description: Homo sapiens somatostatin receptor 3 (SSTR3), transcript variant 1, mRNA. (from RefSeq NM_001051) RefSeq Summary (NM_001051): This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. Gencode Transcript: ENST00000610913.2 Gencode Gene: ENSG00000278195.2 Transcript (Including UTRs) Position: hg38 chr22:37,204,237-37,212,477 Size: 8,241 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr22:37,206,547-37,207,803 Size: 1,257 Coding Exon Count: 1
ID:SSR3_HUMAN DESCRIPTION: RecName: Full=Somatostatin receptor type 3; Short=SS-3-R; Short=SS3-R; Short=SS3R; AltName: Full=SSR-28; FUNCTION: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. INTERACTION: P30874:SSTR2; NbExp=3; IntAct=EBI-6266935, EBI-6266898; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Internalized into endoplasmic vesicles upon somatostatin-stimulation (By similarity). TISSUE SPECIFICITY: Brain, pituitary and pancreas. PTM: Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity). SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P32745
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.