Human Gene SSTR3 (ENST00000610913.2)
  Description: Homo sapiens somatostatin receptor 3 (SSTR3), transcript variant 1, mRNA. (from RefSeq NM_001051)
RefSeq Summary (NM_001051): This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gencode Transcript: ENST00000610913.2
Gencode Gene: ENSG00000278195.2
Transcript (Including UTRs)
   Position: hg38 chr22:37,204,237-37,212,477 Size: 8,241 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr22:37,206,547-37,207,803 Size: 1,257 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:37,204,237-37,212,477)mRNA (may differ from genome)Protein (418 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
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HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: SSR3_HUMAN
DESCRIPTION: RecName: Full=Somatostatin receptor type 3; Short=SS-3-R; Short=SS3-R; Short=SS3R; AltName: Full=SSR-28;
FUNCTION: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
INTERACTION: P30874:SSTR2; NbExp=3; IntAct=EBI-6266935, EBI-6266898;
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Internalized into endoplasmic vesicles upon somatostatin-stimulation (By similarity).
TISSUE SPECIFICITY: Brain, pituitary and pancreas.
PTM: Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: SSTR3
Diseases sorted by gene-association score: pituitary adenoma, prolactin-secreting (3), oncogenic osteomalacia (2), bardet-biedl syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -230.90689-0.335 Picture PostScript Text
3' UTR -1001.602310-0.434 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000586 - Somatstn_rcpt
IPR001856 - Somatstn_rcpt_3

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P32745
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004994 somatostatin receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0042923 neuropeptide binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0007268 chemical synaptic transmission
GO:0007283 spermatogenesis
GO:0008285 negative regulation of cell proliferation
GO:0008628 hormone-mediated apoptotic signaling pathway
GO:0021549 cerebellum development
GO:0030900 forebrain development
GO:0038170 somatostatin signaling pathway
GO:0042594 response to starvation
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071392 cellular response to estradiol stimulus

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0060170 ciliary membrane
GO:0097730 non-motile cilium


-  Descriptions from all associated GenBank mRNAs
  AK291165 - Homo sapiens cDNA FLJ77124 complete cds, highly similar to Homo sapiens somatostatin receptor 3 (SSTR3), mRNA.
CR456585 - Homo sapiens SSTR3 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.SSTR3.V2).
BC096829 - Homo sapiens somatostatin receptor 3, mRNA (cDNA clone MGC:111697 IMAGE:6971896), complete cds.
CU013185 - Homo sapiens SSTR3, mRNA (cDNA clone IMAGE:100000538), complete cds, with stop codon, in Gateway system.
CU013473 - Homo sapiens SSTR3, mRNA (cDNA clone IMAGE:100000442), complete cds, without stop codon, in Gateway system.
AB463273 - Synthetic construct DNA, clone: pF1KB8466, Homo sapiens SSTR3 gene for somatostatin receptor 3, without stop codon, in Flexi system.
BC042068 - Homo sapiens, Similar to somatostatin receptor 3, clone IMAGE:5730411, mRNA, partial cds.
JD119577 - Sequence 100601 from Patent EP1572962.
JD248705 - Sequence 229729 from Patent EP1572962.
JD416071 - Sequence 397095 from Patent EP1572962.
JD060210 - Sequence 41234 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P32745 (Reactome details) participates in the following event(s):

R-HSA-374758 Somatostatin receptors bind somatostatin and cortistatin
R-HSA-5624126 ARL6:GTP and the BBSome bind ciliary cargo
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-5617833 Cilium Assembly
R-HSA-372790 Signaling by GPCR
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K550, ENST00000610913.1, NM_001051, P32745, Q53ZR7, SSR3_HUMAN, uc032qnp.1, uc032qnp.2, uc032qnp.3
UCSC ID: ENST00000610913.2
RefSeq Accession: NM_001051
Protein: P32745 (aka SSR3_HUMAN)
CCDS: CCDS13944.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.