Description: Homo sapiens somatostatin receptor 4 (SSTR4), mRNA. (from RefSeq NM_001052) RefSeq Summary (NM_001052): Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000255008.5 Gencode Gene: ENSG00000132671.6 Transcript (Including UTRs) Position: hg38 chr20:23,035,312-23,039,237 Size: 3,926 Total Exon Count: 1 Strand: + Coding Region Position: hg38 chr20:23,035,484-23,036,650 Size: 1,167 Coding Exon Count: 1
ID:SSR4_HUMAN DESCRIPTION: RecName: Full=Somatostatin receptor type 4; Short=SS-4-R; Short=SS4-R; Short=SS4R; FUNCTION: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P31391
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.