Human Gene SSTR4 (ENST00000255008.5)
  Description: Homo sapiens somatostatin receptor 4 (SSTR4), mRNA. (from RefSeq NM_001052)
RefSeq Summary (NM_001052): Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000255008.5
Gencode Gene: ENSG00000132671.6
Transcript (Including UTRs)
   Position: hg38 chr20:23,035,312-23,039,237 Size: 3,926 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg38 chr20:23,035,484-23,036,650 Size: 1,167 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:23,035,312-23,039,237)mRNA (may differ from genome)Protein (388 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: SSR4_HUMAN
DESCRIPTION: RecName: Full=Somatostatin receptor type 4; Short=SS-4-R; Short=SS4-R; Short=SS4R;
FUNCTION: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.48 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 2.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -96.30172-0.560 Picture PostScript Text
3' UTR -912.002587-0.353 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000586 - Somatstn_rcpt
IPR001512 - Somatstn_rcpt_4

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P31391
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004994 somatostatin receptor activity
GO:0042923 neuropeptide binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 chemical synaptic transmission
GO:0008285 negative regulation of cell proliferation
GO:0016477 cell migration
GO:0019369 arachidonic acid metabolic process
GO:0030815 negative regulation of cAMP metabolic process
GO:0030900 forebrain development
GO:0038170 somatostatin signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0071385 cellular response to glucocorticoid stimulus

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection


-  Descriptions from all associated GenBank mRNAs
  BC117272 - Homo sapiens somatostatin receptor 4, mRNA (cDNA clone MGC:150881 IMAGE:40125823), complete cds.
BC117270 - Homo sapiens somatostatin receptor 4, mRNA (cDNA clone MGC:150879 IMAGE:40125821), complete cds.
KJ905930 - Synthetic construct Homo sapiens clone ccsbBroadEn_15600 SSTR4 gene, encodes complete protein.
KJ892209 - Synthetic construct Homo sapiens clone ccsbBroadEn_01603 SSTR4 gene, encodes complete protein.
BC069063 - Homo sapiens somatostatin receptor 4, mRNA (cDNA clone MGC:95337 IMAGE:7216876), complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P31391 (Reactome details) participates in the following event(s):

R-HSA-374758 Somatostatin receptors bind somatostatin and cortistatin
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000255008.1, ENST00000255008.2, ENST00000255008.3, ENST00000255008.4, NM_001052, P31391, Q17RM1, Q17RM3, Q9UIY1, SSR4_HUMAN, uc002wsr.1, uc002wsr.2, uc002wsr.3, uc002wsr.4
UCSC ID: ENST00000255008.5
RefSeq Accession: NM_001052
Protein: P31391 (aka SSR4_HUMAN)
CCDS: CCDS42856.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.