Human Gene ADCYAP1R1 (ENST00000304166.9)
  Description: Homo sapiens ADCYAP receptor type I (ADCYAP1R1), transcript variant 3, mRNA. (from RefSeq NM_001118)
RefSeq Summary (NM_001118): This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010].
Gencode Transcript: ENST00000304166.9
Gencode Gene: ENSG00000078549.15
Transcript (Including UTRs)
   Position: hg38 chr7:31,052,308-31,111,474 Size: 59,167 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg38 chr7:31,063,265-31,106,684 Size: 43,420 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:31,052,308-31,111,474)mRNA (may differ from genome)Protein (468 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Pituitary adenylate cyclase-activating polypeptide type I receptor; Short=PACAP type I receptor; Short=PACAP-R-1; Short=PACAP-R1; Flags: Precursor;
FUNCTION: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
SUBUNIT: Interacts (via N-terminal extracellular domain) with ADCYAP1.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
SEQUENCE CAUTION: Sequence=BAA04466.1; Type=Erroneous initiation;

-  MalaCards Disease Associations
  MalaCards Gene Search: ADCYAP1R1
Diseases sorted by gene-association score: post-traumatic stress disorder (10), anxiety disorder (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.03 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 386.93 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -254.00442-0.575 Picture PostScript Text
3' UTR -1781.204790-0.372 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017981 - GPCR_2-like
IPR001879 - GPCR_2_extracellular_dom
IPR002285 - GPCR_2_PACAP_1_rcpt
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF02793 - Hormone receptor domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help


- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P41586
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004999 vasoactive intestinal polypeptide receptor activity
GO:0005515 protein binding
GO:0008179 adenylate cyclase binding
GO:0030306 ADP-ribosylation factor binding
GO:0038023 signaling receptor activity
GO:0042923 neuropeptide binding

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0019933 cAMP-mediated signaling
GO:0030154 cell differentiation
GO:0032355 response to estradiol
GO:0033555 multicellular organismal response to stress
GO:0042493 response to drug
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045471 response to ethanol
GO:0046545 development of primary female sexual characteristics
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0060548 negative regulation of cell death
GO:0060732 positive regulation of inositol phosphate biosynthetic process

Cellular Component:
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005791 rough endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005923 bicellular tight junction
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex

-  Descriptions from all associated GenBank mRNAs
  AK290046 - Homo sapiens cDNA FLJ76767 complete cds, highly similar to Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1), mRNA.
AK226138 - Homo sapiens mRNA for type I adenylate cyclase activating polypeptide receptor precursor variant, clone: pf00023.
BC136267 - Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, mRNA (cDNA clone MGC:167877 IMAGE:9020254), complete cds.
BC117116 - Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, mRNA (cDNA clone MGC:150725 IMAGE:40125667), complete cds.
BC143679 - Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, mRNA (cDNA clone MGC:177210 IMAGE:9052193), complete cds.
D17516 - Homo sapiens mRNA for PACAP receptor, complete cds.
E10374 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-A.
E10375 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-B.
E10376 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-B2.
E10377 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-C.
HQ258442 - Synthetic construct Homo sapiens clone IMAGE:100072871 Unknown protein gene, encodes complete protein.
AY366498 - Homo sapiens pituitary adenyl cyclase activating polypeptide 1 receptor type 1 (ADCYAP1R1) mRNA, complete cds.
AY462278 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop splice variant (ADCYAP1R1) mRNA, partial cds; alternatively spliced.
AY462279 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I Hop splice variant (ADCYAP1R1) mRNA, partial cds; alternatively spliced.
AY495951 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I Hip variant (ADCYAP1R1) mRNA, partial cds, alternatively spliced.
AY495952 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I HopII variant (ADCYAP1R1) mRNA, partial cds, alternatively spliced.
BX538156 - Homo sapiens mRNA; cDNA DKFZp686A0650 (from clone DKFZp686A0650).
AK096545 - Homo sapiens cDNA FLJ39226 fis, clone OCBBF2007232.
JD356047 - Sequence 337071 from Patent EP1572962.
JD378114 - Sequence 359138 from Patent EP1572962.
JD200042 - Sequence 181066 from Patent EP1572962.
JD490579 - Sequence 471603 from Patent EP1572962.
JD466532 - Sequence 447556 from Patent EP1572962.
JD545893 - Sequence 526917 from Patent EP1572962.
JD088716 - Sequence 69740 from Patent EP1572962.
JD330436 - Sequence 311460 from Patent EP1572962.
JD175240 - Sequence 156264 from Patent EP1572962.
JD424643 - Sequence 405667 from Patent EP1572962.
JD448905 - Sequence 429929 from Patent EP1572962.
JD190098 - Sequence 171122 from Patent EP1572962.
JD271204 - Sequence 252228 from Patent EP1572962.
JD536141 - Sequence 517165 from Patent EP1572962.
JD402628 - Sequence 383652 from Patent EP1572962.
JD411584 - Sequence 392608 from Patent EP1572962.
JD264643 - Sequence 245667 from Patent EP1572962.
JD208335 - Sequence 189359 from Patent EP1572962.
JD491112 - Sequence 472136 from Patent EP1572962.
JD490567 - Sequence 471591 from Patent EP1572962.
JD200954 - Sequence 181978 from Patent EP1572962.
AK124304 - Homo sapiens cDNA FLJ42311 fis, clone TRACH2008300.
JD290960 - Sequence 271984 from Patent EP1572962.
JD237444 - Sequence 218468 from Patent EP1572962.
JD545637 - Sequence 526661 from Patent EP1572962.
JD566290 - Sequence 547314 from Patent EP1572962.
JD444097 - Sequence 425121 from Patent EP1572962.
JD213804 - Sequence 194828 from Patent EP1572962.
JD430846 - Sequence 411870 from Patent EP1572962.
JD326333 - Sequence 307357 from Patent EP1572962.
JD492850 - Sequence 473874 from Patent EP1572962.
JD218656 - Sequence 199680 from Patent EP1572962.
JD494711 - Sequence 475735 from Patent EP1572962.
JD453035 - Sequence 434059 from Patent EP1572962.
JD135074 - Sequence 116098 from Patent EP1572962.
JD092677 - Sequence 73701 from Patent EP1572962.
JD243125 - Sequence 224149 from Patent EP1572962.
JD344612 - Sequence 325636 from Patent EP1572962.
JD048611 - Sequence 29635 from Patent EP1572962.
JD369620 - Sequence 350644 from Patent EP1572962.
JD340497 - Sequence 321521 from Patent EP1572962.
JD368967 - Sequence 349991 from Patent EP1572962.
JD263090 - Sequence 244114 from Patent EP1572962.
JD293792 - Sequence 274816 from Patent EP1572962.
JD536838 - Sequence 517862 from Patent EP1572962.
JD524118 - Sequence 505142 from Patent EP1572962.
JD206361 - Sequence 187385 from Patent EP1572962.
JD231824 - Sequence 212848 from Patent EP1572962.
JD247863 - Sequence 228887 from Patent EP1572962.
JD444530 - Sequence 425554 from Patent EP1572962.
JD137293 - Sequence 118317 from Patent EP1572962.
JD162502 - Sequence 143526 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P41586 (Reactome details) participates in the following event(s):

R-HSA-187678 TRKA activation by PACAP type 1 receptor
R-HSA-420131 The PACAP receptor binds PACAP
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-187024 NGF-independant TRKA activation
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-187015 Activation of TRKA receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-166520 Signaling by NTRKs
R-HSA-372790 Signaling by GPCR
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K1Y1, B7ZLA7, B8ZZK3, ENST00000304166.1, ENST00000304166.2, ENST00000304166.3, ENST00000304166.4, ENST00000304166.5, ENST00000304166.6, ENST00000304166.7, ENST00000304166.8, NM_001118, P41586, PACR_HUMAN, Q17S10, uc003tca.1, uc003tca.2, uc003tca.3, uc003tca.4
UCSC ID: ENST00000304166.9
RefSeq Accession: NM_001118
Protein: P41586 (aka PACR_HUMAN)
CCDS: CCDS5433.1, CCDS56481.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.