Human Gene GPX5 (ENST00000412168.7) from GENCODE V44
Description: Homo sapiens glutathione peroxidase 5 (GPX5), transcript variant 1, mRNA. (from RefSeq NM_001509) RefSeq Summary (NM_001509): This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]. Gencode Transcript: ENST00000412168.7 Gencode Gene: ENSG00000224586.7 Transcript (Including UTRs) Position: hg38 chr6:28,525,881-28,534,955 Size: 9,075 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr6:28,526,014-28,534,167 Size: 8,154 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.