Human Gene GPX5 (ENST00000412168.7) from GENCODE V44
  Description: Homo sapiens glutathione peroxidase 5 (GPX5), transcript variant 1, mRNA. (from RefSeq NM_001509)
RefSeq Summary (NM_001509): This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016].
Gencode Transcript: ENST00000412168.7
Gencode Gene: ENSG00000224586.7
Transcript (Including UTRs)
   Position: hg38 chr6:28,525,881-28,534,955 Size: 9,075 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr6:28,526,014-28,534,167 Size: 8,154 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:28,525,881-28,534,955)mRNA (may differ from genome)Protein (221 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.60 RPKM in Testis
Total median expression: 2.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.30133-0.333 Picture PostScript Text
3' UTR -208.00788-0.264 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  BC128159 - Homo sapiens glutathione peroxidase 5 (epididymal androgen-related protein), mRNA (cDNA clone IMAGE:40112992), complete cds.
BC128160 - Homo sapiens glutathione peroxidase 5 (epididymal androgen-related protein), mRNA (cDNA clone IMAGE:40113000), complete cds.
AJ005277 - Homo sapiens mRNA for glutathione peroxidase type 5 (GPX5).
FJ460514 - Homo sapiens epididymis secretory sperm binding protein Li 75p (HEL-S-75p) mRNA, complete cds.
AB463692 - Synthetic construct DNA, clone: pF1KB7184, Homo sapiens GPX5 gene for glutathione peroxidase 5, without stop codon, in Flexi system.
BC111375 - Synthetic construct Homo sapiens clone IMAGE:40080648, MGC:133436 GPX5 protein (GPX5) mRNA, encodes complete protein.
AK093099 - Homo sapiens cDNA FLJ35780 fis, clone TESTI2005391, highly similar to Homo sapiens glutathione peroxidase 5 (epididymal androgen-related protein) (GPX5), transcript variant 2, mRNA.
JD117967 - Sequence 98991 from Patent EP1572962.
JD109761 - Sequence 90785 from Patent EP1572962.
JD438565 - Sequence 419589 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00480 - Glutathione metabolism
hsa00590 - Arachidonic acid metabolism

BioCyc Knowledge Library
DETOX1-PWY-1 - reactive oxygen species degradation

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000412168.1, ENST00000412168.2, ENST00000412168.3, ENST00000412168.4, ENST00000412168.5, ENST00000412168.6, NM_001509, uc003nll.1, uc003nll.2, uc003nll.3, uc003nll.4, V9HWN8
UCSC ID: ENST00000412168.7
RefSeq Accession: NM_001509
CCDS: CCDS4652.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.