Human Gene CAT (ENST00000241052.5) from GENCODE V44
Description: Homo sapiens catalase (CAT), mRNA. (from RefSeq NM_001752) RefSeq Summary (NM_001752): This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]. Gencode Transcript: ENST00000241052.5 Gencode Gene: ENSG00000121691.7 Transcript (Including UTRs) Position: hg38 chr11:34,438,934-34,472,060 Size: 33,127 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr11:34,439,014-34,471,433 Size: 32,420 Coding Exon Count: 13
ID:CATA_HUMAN DESCRIPTION: RecName: Full=Catalase; EC=1.11.1.6; FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. CATALYTIC ACTIVITY: 2 H(2)O(2) = O(2) + 2 H(2)O. COFACTOR: Heme group. COFACTOR: NADP. SUBUNIT: Homotetramer. SUBCELLULAR LOCATION: Peroxisome. PTM: The N-terminus is blocked. DISEASE: Defects in CAT are the cause of acatalasemia (ACATLAS) [MIM:614097]. A metabolic disorder characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions. SIMILARITY: Belongs to the catalase family. WEB RESOURCE: Name=Wikipedia; Note=Catalase entry; URL="http://en.wikipedia.org/wiki/Catalase"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cat/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P04040
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.