Human Gene GH2 (ENST00000423893.7) Description and Page Index
Description: Homo sapiens growth hormone 2 (GH2), transcript variant 1, mRNA. (from RefSeq NM_002059) RefSeq Summary (NM_002059): The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000423893.7 Gencode Gene: ENSG00000136487.18 Transcript (Including UTRs) Position: hg38 chr17:63,880,215-63,881,944 Size: 1,730 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr17:63,880,321-63,881,801 Size: 1,481 Coding Exon Count: 5
ID:SOM2_HUMAN DESCRIPTION: RecName: Full=Growth hormone variant; Short=GH-V; AltName: Full=Growth hormone 2; AltName: Full=Placenta-specific growth hormone; Flags: Precursor; FUNCTION: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. SUBUNIT: Monomer, dimer, trimer, tetramer and pentamer, disulfide- linked or non-covalently associated, in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in the placenta. SIMILARITY: Belongs to the somatotropin/prolactin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00103 - Somatotropin hormone family
ModBase Predicted Comparative 3D Structure on P01242
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.