Human Gene INHBA (ENST00000242208.5)
  Description: Homo sapiens inhibin subunit beta A (INHBA), mRNA. (from RefSeq NM_002192)
RefSeq Summary (NM_002192): This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000242208.5
Gencode Gene: ENSG00000122641.11
Transcript (Including UTRs)
   Position: hg38 chr7:41,685,114-41,703,090 Size: 17,977 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr7:41,689,650-41,700,374 Size: 10,725 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:41,685,114-41,703,090)mRNA (may differ from genome)Protein (426 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: INHBA_HUMAN
DESCRIPTION: RecName: Full=Inhibin beta A chain; AltName: Full=Activin beta-A chain; AltName: Full=Erythroid differentiation protein; Short=EDF; Flags: Precursor;
FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
SUBUNIT: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the TGF-beta family.
WEB RESOURCE: Name=Wikipedia; Note=Activin entry; URL="http://en.wikipedia.org/wiki/Activin";

-  MalaCards Disease Associations
  MalaCards Gene Search: INHBA
Diseases sorted by gene-association score: ovary adenocarcinoma* (350), preterm premature rupture of the membranes (8), myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.65 RPKM in Artery - Tibial
Total median expression: 62.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.15229-0.184 Picture PostScript Text
3' UTR -1122.004536-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000491 - Inhibin_betaA
IPR001839 - TGF-b_C
IPR001111 - TGF-b_N
IPR015615 - TGF-beta-rel
IPR017948 - TGFb_CS

Pfam Domains:
PF00019 - Transforming growth factor beta like domain
PF00688 - TGF-beta propeptide

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1NYS
- X-ray MuPIT

1NYU
- X-ray MuPIT

1S4Y
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
2ARP - X-ray MuPIT 2ARV - X-ray MuPIT 2B0U - X-ray MuPIT
2P6A - X-ray MuPIT 3B4V - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P08476
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0017046 peptide hormone binding
GO:0034711 inhibin binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0070699 type II activin receptor binding

Biological Process:
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001541 ovarian follicle development
GO:0001707 mesoderm formation
GO:0001942 hair follicle development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006952 defense response
GO:0007050 cell cycle arrest
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0010469 regulation of receptor activity
GO:0010628 positive regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0021773 striatal medium spiny neuron differentiation
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030308 negative regulation of cell growth
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032924 activin receptor signaling pathway
GO:0035987 endodermal cell differentiation
GO:0042326 negative regulation of phosphorylation
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0042541 hemoglobin biosynthetic process
GO:0042701 progesterone secretion
GO:0043408 regulation of MAPK cascade
GO:0045077 negative regulation of interferon-gamma biosynthetic process
GO:0045578 negative regulation of B cell differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045650 negative regulation of macrophage differentiation
GO:0045786 negative regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046880 regulation of follicle-stimulating hormone secretion
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0046882 negative regulation of follicle-stimulating hormone secretion
GO:0048333 mesodermal cell differentiation
GO:0048468 cell development
GO:0060021 palate development
GO:0060279 positive regulation of ovulation
GO:0060395 SMAD protein signal transduction
GO:0061029 eyelid development in camera-type eye
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071397 cellular response to cholesterol
GO:0097154 GABAergic neuron differentiation
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0009611 response to wounding

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0043509 activin A complex
GO:0043512 inhibin A complex
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF209689 - JP 2014500723-A/17192: Polycomb-Associated Non-Coding RNAs.
MA445266 - JP 2018138019-A/17192: Polycomb-Associated Non-Coding RNAs.
AK001903 - Homo sapiens cDNA FLJ11041 fis, clone PLACE1004405.
LF331009 - JP 2014500723-A/138512: Polycomb-Associated Non-Coding RNAs.
MA566586 - JP 2018138019-A/138512: Polycomb-Associated Non-Coding RNAs.
LF331008 - JP 2014500723-A/138511: Polycomb-Associated Non-Coding RNAs.
MA566585 - JP 2018138019-A/138511: Polycomb-Associated Non-Coding RNAs.
LF331007 - JP 2014500723-A/138510: Polycomb-Associated Non-Coding RNAs.
MA566584 - JP 2018138019-A/138510: Polycomb-Associated Non-Coding RNAs.
LF331006 - JP 2014500723-A/138509: Polycomb-Associated Non-Coding RNAs.
MA566583 - JP 2018138019-A/138509: Polycomb-Associated Non-Coding RNAs.
LF331005 - JP 2014500723-A/138508: Polycomb-Associated Non-Coding RNAs.
MA566582 - JP 2018138019-A/138508: Polycomb-Associated Non-Coding RNAs.
LF331004 - JP 2014500723-A/138507: Polycomb-Associated Non-Coding RNAs.
MA566581 - JP 2018138019-A/138507: Polycomb-Associated Non-Coding RNAs.
LF331003 - JP 2014500723-A/138506: Polycomb-Associated Non-Coding RNAs.
MA566580 - JP 2018138019-A/138506: Polycomb-Associated Non-Coding RNAs.
LF331002 - JP 2014500723-A/138505: Polycomb-Associated Non-Coding RNAs.
MA566579 - JP 2018138019-A/138505: Polycomb-Associated Non-Coding RNAs.
LF331001 - JP 2014500723-A/138504: Polycomb-Associated Non-Coding RNAs.
MA566578 - JP 2018138019-A/138504: Polycomb-Associated Non-Coding RNAs.
LF331000 - JP 2014500723-A/138503: Polycomb-Associated Non-Coding RNAs.
MA566577 - JP 2018138019-A/138503: Polycomb-Associated Non-Coding RNAs.
LF330999 - JP 2014500723-A/138502: Polycomb-Associated Non-Coding RNAs.
MA566576 - JP 2018138019-A/138502: Polycomb-Associated Non-Coding RNAs.
LF330998 - JP 2014500723-A/138501: Polycomb-Associated Non-Coding RNAs.
MA566575 - JP 2018138019-A/138501: Polycomb-Associated Non-Coding RNAs.
LF330997 - JP 2014500723-A/138500: Polycomb-Associated Non-Coding RNAs.
MA566574 - JP 2018138019-A/138500: Polycomb-Associated Non-Coding RNAs.
LF330996 - JP 2014500723-A/138499: Polycomb-Associated Non-Coding RNAs.
MA566573 - JP 2018138019-A/138499: Polycomb-Associated Non-Coding RNAs.
LF384902 - JP 2014500723-A/192405: Polycomb-Associated Non-Coding RNAs.
MA620479 - JP 2018138019-A/192405: Polycomb-Associated Non-Coding RNAs.
J03634 - Human erythroid differentiation protein mRNA (EDF), complete cds.
E01797 - cDNA encoding human differentiation-inducing factor,BUF-3.
E02200 - DNA encoding differentiation-inducing factor (BUF-3).
LF330995 - JP 2014500723-A/138498: Polycomb-Associated Non-Coding RNAs.
MA566572 - JP 2018138019-A/138498: Polycomb-Associated Non-Coding RNAs.
JD391358 - Sequence 372382 from Patent EP1572962.
LF330994 - JP 2014500723-A/138497: Polycomb-Associated Non-Coding RNAs.
MA566571 - JP 2018138019-A/138497: Polycomb-Associated Non-Coding RNAs.
BX648811 - Homo sapiens mRNA; cDNA DKFZp686A06204 (from clone DKFZp686A06204).
AF218018 - Homo sapiens clone PP5378 unknown mRNA.
BC007858 - Homo sapiens inhibin, beta A, mRNA (cDNA clone MGC:14383 IMAGE:4299832), complete cds.
LF209688 - JP 2014500723-A/17191: Polycomb-Associated Non-Coding RNAs.
MA445265 - JP 2018138019-A/17191: Polycomb-Associated Non-Coding RNAs.
M13436 - Human ovarian beta-A inhibin mRNA, complete cds.
AK222742 - Homo sapiens mRNA for inhibin beta A subunit precursor variant, clone: DMC07551.
LF214000 - JP 2014500723-A/21503: Polycomb-Associated Non-Coding RNAs.
MA449577 - JP 2018138019-A/21503: Polycomb-Associated Non-Coding RNAs.
JD330589 - Sequence 311613 from Patent EP1572962.
LF330993 - JP 2014500723-A/138496: Polycomb-Associated Non-Coding RNAs.
MA566570 - JP 2018138019-A/138496: Polycomb-Associated Non-Coding RNAs.
JD222306 - Sequence 203330 from Patent EP1572962.
JD206383 - Sequence 187407 from Patent EP1572962.
AK290584 - Homo sapiens cDNA FLJ75379 complete cds, highly similar to Homo sapiens inhibin, beta A (activin A, activin AB alpha polypeptide), mRNA.
DQ893158 - Synthetic construct clone IMAGE:100005788; FLH194442.01X; RZPDo839B0580D inhibin, beta A (activin A, activin AB alpha polypeptide) (INHBA) gene, encodes complete protein.
KJ891477 - Synthetic construct Homo sapiens clone ccsbBroadEn_00871 INHBA gene, encodes complete protein.
DQ896452 - Synthetic construct Homo sapiens clone IMAGE:100010912; FLH194438.01L; RZPDo839B0570D inhibin, beta A (activin A, activin AB alpha polypeptide) (INHBA) gene, encodes complete protein.
AB464591 - Synthetic construct DNA, clone: pF1KB7035, Homo sapiens INHBA gene for inhibin, beta A, without stop codon, in Flexi system.
X72498 - H.sapiens mRNA for inhibin beta(A) subunit.
LF330992 - JP 2014500723-A/138495: Polycomb-Associated Non-Coding RNAs.
MA566569 - JP 2018138019-A/138495: Polycomb-Associated Non-Coding RNAs.
CU675839 - Synthetic construct Homo sapiens gateway clone IMAGE:100017243 5' read INHBA mRNA.
DQ597848 - Homo sapiens piRNA piR-35914, complete sequence.
LF330991 - JP 2014500723-A/138494: Polycomb-Associated Non-Coding RNAs.
MA566568 - JP 2018138019-A/138494: Polycomb-Associated Non-Coding RNAs.
LF330990 - JP 2014500723-A/138493: Polycomb-Associated Non-Coding RNAs.
MA566567 - JP 2018138019-A/138493: Polycomb-Associated Non-Coding RNAs.
LF330989 - JP 2014500723-A/138492: Polycomb-Associated Non-Coding RNAs.
MA566566 - JP 2018138019-A/138492: Polycomb-Associated Non-Coding RNAs.
LF330988 - JP 2014500723-A/138491: Polycomb-Associated Non-Coding RNAs.
MA566565 - JP 2018138019-A/138491: Polycomb-Associated Non-Coding RNAs.
LF330984 - JP 2014500723-A/138487: Polycomb-Associated Non-Coding RNAs.
MA566561 - JP 2018138019-A/138487: Polycomb-Associated Non-Coding RNAs.
LF330983 - JP 2014500723-A/138486: Polycomb-Associated Non-Coding RNAs.
MA566560 - JP 2018138019-A/138486: Polycomb-Associated Non-Coding RNAs.
LF330982 - JP 2014500723-A/138485: Polycomb-Associated Non-Coding RNAs.
MA566559 - JP 2018138019-A/138485: Polycomb-Associated Non-Coding RNAs.
D49743 - Homo sapiens mRNA for activin beta-A, exon1,2.
LF330981 - JP 2014500723-A/138484: Polycomb-Associated Non-Coding RNAs.
MA566558 - JP 2018138019-A/138484: Polycomb-Associated Non-Coding RNAs.
LF330980 - JP 2014500723-A/138483: Polycomb-Associated Non-Coding RNAs.
MA566557 - JP 2018138019-A/138483: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04060 - Cytokine-cytokine receptor interaction
hsa04350 - TGF-beta signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein P08476 (Reactome details) participates in the following event(s):

R-HSA-1181153 Activin A/AB/B binds Activin Receptor ACVR2A/B:ACVR1B
R-HSA-2473184 Follistatin (FST) binds Activin
R-HSA-2473186 FSTL3 binds Activin
R-HSA-2470483 Activin AB/B binds Activin Receptor ACVR2A/B:ACVR1C
R-HSA-1181149 ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin
R-HSA-2470508 ACVR2A/B (ActRIIA/B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin
R-HSA-1549526 Phosphorylation of SMAD2/3 by Activin:Activin Receptor
R-HSA-1502540 Signaling by Activin
R-HSA-2473224 Antagonism of Activin by Follistatin
R-HSA-9006936 Signaling by TGF-beta family members
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000242208.1, ENST00000242208.2, ENST00000242208.3, ENST00000242208.4, INHBA_HUMAN, NM_002192, P08476, Q14599, uc003thr.1, uc003thr.2, uc003thr.3, uc003thr.4, uc003thr.5
UCSC ID: ENST00000242208.5
RefSeq Accession: NM_002192
Protein: P08476 (aka INHBA_HUMAN or IHBA_HUMAN)
CCDS: CCDS5464.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.