Human Gene INHBB (ENST00000295228.4)
  Description: Homo sapiens inhibin subunit beta B (INHBB), mRNA. (from RefSeq NM_002193)
RefSeq Summary (NM_002193): This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016].
Gencode Transcript: ENST00000295228.4
Gencode Gene: ENSG00000163083.6
Transcript (Including UTRs)
   Position: hg38 chr2:120,346,136-120,351,803 Size: 5,668 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr2:120,346,189-120,349,874 Size: 3,686 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:120,346,136-120,351,803)mRNA (may differ from genome)Protein (407 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: INHBB_HUMAN
DESCRIPTION: RecName: Full=Inhibin beta B chain; AltName: Full=Activin beta-B chain; Flags: Precursor;
FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
SUBUNIT: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the TGF-beta family.
WEB RESOURCE: Name=Wikipedia; Note=Inhibin entry; URL="http://en.wikipedia.org/wiki/Inhibin";

-  MalaCards Disease Associations
  MalaCards Gene Search: INHBB
Diseases sorted by gene-association score: pre-eclampsia (13), eclampsia (10), epididymo-orchitis (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.89 RPKM in Adipose - Subcutaneous
Total median expression: 274.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.2053-0.400 Picture PostScript Text
3' UTR -627.101929-0.325 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000381 - Inhibin_betaB
IPR001839 - TGF-b_C
IPR001111 - TGF-b_N
IPR015615 - TGF-beta-rel
IPR017948 - TGFb_CS

Pfam Domains:
PF00019 - Transforming growth factor beta like domain
PF00688 - TGF-beta propeptide

ModBase Predicted Comparative 3D Structure on P09529
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
GO:0046789 host cell surface receptor binding

Biological Process:
GO:0001541 ovarian follicle development
GO:0006952 defense response
GO:0009267 cellular response to starvation
GO:0009611 response to wounding
GO:0010469 regulation of receptor activity
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030154 cell differentiation
GO:0032869 cellular response to insulin stimulus
GO:0032924 activin receptor signaling pathway
GO:0042981 regulation of apoptotic process
GO:0043408 regulation of MAPK cascade
GO:0044320 cellular response to leptin stimulus
GO:0044650 adhesion of symbiont to host cell
GO:0045444 fat cell differentiation
GO:0046676 negative regulation of insulin secretion
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0046882 negative regulation of follicle-stimulating hormone secretion
GO:0048178 negative regulation of hepatocyte growth factor biosynthetic process
GO:0048468 cell development
GO:0048599 oocyte development
GO:0060279 positive regulation of ovulation
GO:0060395 SMAD protein signal transduction
GO:2001235 positive regulation of apoptotic signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery


-  Descriptions from all associated GenBank mRNAs
  BC030029 - Homo sapiens inhibin, beta B, mRNA (cDNA clone MGC:33716 IMAGE:5258851), complete cds.
DQ890708 - Synthetic construct clone IMAGE:100003338; FLH165336.01X; RZPDo839B01160D inhibin, beta B (activin AB beta polypeptide) (INHBB) gene, encodes complete protein.
AB463775 - Synthetic construct DNA, clone: pF1KB8996, Homo sapiens INHBB gene for inhibin, beta B, without stop codon, in Flexi system.
M31682 - Human testicular inhibin beta-B-subunit mRNA, 3' end.
M13437 - Human ovarian beta-B inhibin mRNA.
JD484389 - Sequence 465413 from Patent EP1572962.
JD162590 - Sequence 143614 from Patent EP1572962.
JD142511 - Sequence 123535 from Patent EP1572962.
JD319040 - Sequence 300064 from Patent EP1572962.
JD283990 - Sequence 265014 from Patent EP1572962.
JD098247 - Sequence 79271 from Patent EP1572962.
JD454695 - Sequence 435719 from Patent EP1572962.
JD115681 - Sequence 96705 from Patent EP1572962.
JD121268 - Sequence 102292 from Patent EP1572962.
JD400097 - Sequence 381121 from Patent EP1572962.
JD401314 - Sequence 382338 from Patent EP1572962.
JD151692 - Sequence 132716 from Patent EP1572962.
JD522671 - Sequence 503695 from Patent EP1572962.
JD165169 - Sequence 146193 from Patent EP1572962.
JD467917 - Sequence 448941 from Patent EP1572962.
JD076121 - Sequence 57145 from Patent EP1572962.
JD306469 - Sequence 287493 from Patent EP1572962.
JD278858 - Sequence 259882 from Patent EP1572962.
JD343266 - Sequence 324290 from Patent EP1572962.
JD308472 - Sequence 289496 from Patent EP1572962.
JD053172 - Sequence 34196 from Patent EP1572962.
BC127815 - Homo sapiens inhibin, beta B, mRNA (cDNA clone IMAGE:40133983), complete cds.
JD485901 - Sequence 466925 from Patent EP1572962.
JD106413 - Sequence 87437 from Patent EP1572962.
JD381090 - Sequence 362114 from Patent EP1572962.
JD476416 - Sequence 457440 from Patent EP1572962.
JD405838 - Sequence 386862 from Patent EP1572962.
JD048806 - Sequence 29830 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04060 - Cytokine-cytokine receptor interaction
hsa04350 - TGF-beta signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein P09529 (Reactome details) participates in the following event(s):

R-HSA-2470483 Activin AB/B binds Activin Receptor ACVR2A/B:ACVR1C
R-HSA-1181153 Activin A/AB/B binds Activin Receptor ACVR2A/B:ACVR1B
R-HSA-2473184 Follistatin (FST) binds Activin
R-HSA-2473186 FSTL3 binds Activin
R-HSA-2470508 ACVR2A/B (ActRIIA/B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin
R-HSA-1181149 ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin
R-HSA-1549526 Phosphorylation of SMAD2/3 by Activin:Activin Receptor
R-HSA-1502540 Signaling by Activin
R-HSA-2473224 Antagonism of Activin by Follistatin
R-HSA-9006936 Signaling by TGF-beta family members
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000295228.1, ENST00000295228.2, ENST00000295228.3, INHBB_HUMAN, NM_002193, P09529, Q53T31, Q8N1D3, uc002tmn.1, uc002tmn.2, uc002tmn.3, uc002tmn.4
UCSC ID: ENST00000295228.4
RefSeq Accession: NM_002193
Protein: P09529 (aka INHBB_HUMAN or IHBB_HUMAN)
CCDS: CCDS2132.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.