Human Gene NTSR1 (ENST00000370501.4)
  Description: Homo sapiens neurotensin receptor 1 (NTSR1), mRNA. (from RefSeq NM_002531)
RefSeq Summary (NM_002531): Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000370501.4
Gencode Gene: ENSG00000101188.5
Transcript (Including UTRs)
   Position: hg38 chr20:62,708,836-62,762,771 Size: 53,936 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr20:62,709,208-62,760,267 Size: 51,060 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr20:62,708,836-62,762,771)mRNA (may differ from genome)Protein (418 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Neurotensin receptor type 1; Short=NT-R-1; Short=NTR1; AltName: Full=High-affinity levocabastine-insensitive neurotensin receptor; AltName: Full=NTRH;
FUNCTION: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.
WEB RESOURCE: Name=Wikipedia; Note=Neurotensin receptor entry; URL="";

-  MalaCards Disease Associations
  MalaCards Gene Search: NTSR1
Diseases sorted by gene-association score: patellofemoral pain syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.73 RPKM in Colon - Sigmoid
Total median expression: 27.88 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -194.40372-0.523 Picture PostScript Text
3' UTR -1085.102504-0.433 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR003985 - NT1_rcpt
IPR003984 - NT_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P30989
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016492 G-protein coupled neurotensin receptor activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0047485 protein N-terminus binding

Biological Process:
GO:0001659 temperature homeostasis
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0003254 regulation of membrane depolarization
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007612 learning
GO:0008344 adult locomotory behavior
GO:0014049 positive regulation of glutamate secretion
GO:0014054 positive regulation of gamma-aminobutyric acid secretion
GO:0033993 response to lipid
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043576 regulation of respiratory gaseous exchange
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051930 regulation of sensory perception of pain
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0070779 D-aspartate import
GO:0071545 inositol phosphate catabolic process
GO:0090238 positive regulation of arachidonic acid secretion
GO:0097151 positive regulation of inhibitory postsynaptic potential
GO:0098712 L-glutamate import across plasma membrane
GO:0098900 regulation of action potential
GO:2001259 positive regulation of cation channel activity

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0032280 symmetric synapse
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0044309 neuron spine
GO:0045121 membrane raft
GO:0045202 synapse

-  Descriptions from all associated GenBank mRNAs
  X70070 - H.sapiens mRNA for neurotensin receptor.
JD462124 - Sequence 443148 from Patent EP1572962.
JD462125 - Sequence 443149 from Patent EP1572962.
JD473838 - Sequence 454862 from Patent EP1572962.
JD104625 - Sequence 85649 from Patent EP1572962.
JD494445 - Sequence 475469 from Patent EP1572962.
JD192385 - Sequence 173409 from Patent EP1572962.
JD226485 - Sequence 207509 from Patent EP1572962.
JD226486 - Sequence 207510 from Patent EP1572962.
JD399584 - Sequence 380608 from Patent EP1572962.
JD326501 - Sequence 307525 from Patent EP1572962.
BC152809 - Synthetic construct Homo sapiens clone IMAGE:100016033, MGC:184126 neurotensin receptor 1 (high affinity) (NTSR1) mRNA, encodes complete protein.
AB528781 - Synthetic construct DNA, clone: pF1KE0246, Homo sapiens NTSR1 gene for neurotensin receptor 1, without stop codon, in Flexi system.
E11480 - cDNA encoding human neurotensin receptor protein.
AY429106 - Homo sapiens neurotensin receptor 1 mRNA, complete cds.
CS111418 - Sequence 5 from Patent WO2005052194.
CS111421 - Sequence 8 from Patent WO2005052194.
CS111424 - Sequence 11 from Patent WO2005052194.
CS111427 - Sequence 14 from Patent WO2005052194.
CS111430 - Sequence 17 from Patent WO2005052194.
CS111433 - Sequence 20 from Patent WO2005052194.
CS111436 - Sequence 23 from Patent WO2005052194.
CS111439 - Sequence 26 from Patent WO2005052194.
JD103867 - Sequence 84891 from Patent EP1572962.
JD485774 - Sequence 466798 from Patent EP1572962.
JD486037 - Sequence 467061 from Patent EP1572962.
JD186400 - Sequence 167424 from Patent EP1572962.
JD525003 - Sequence 506027 from Patent EP1572962.
JD121735 - Sequence 102759 from Patent EP1572962.
JD154480 - Sequence 135504 from Patent EP1572962.
JD263548 - Sequence 244572 from Patent EP1572962.
JD231323 - Sequence 212347 from Patent EP1572962.
JD408473 - Sequence 389497 from Patent EP1572962.
JD395110 - Sequence 376134 from Patent EP1572962.
JD565710 - Sequence 546734 from Patent EP1572962.
JD459837 - Sequence 440861 from Patent EP1572962.
JD544337 - Sequence 525361 from Patent EP1572962.
JD445831 - Sequence 426855 from Patent EP1572962.
JD470290 - Sequence 451314 from Patent EP1572962.
JD310110 - Sequence 291134 from Patent EP1572962.
JD209918 - Sequence 190942 from Patent EP1572962.
JD479222 - Sequence 460246 from Patent EP1572962.
JD481782 - Sequence 462806 from Patent EP1572962.
JD167470 - Sequence 148494 from Patent EP1572962.
JD078823 - Sequence 59847 from Patent EP1572962.
JD276478 - Sequence 257502 from Patent EP1572962.
JD282939 - Sequence 263963 from Patent EP1572962.
JD109001 - Sequence 90025 from Patent EP1572962.
JD354117 - Sequence 335141 from Patent EP1572962.
JD269962 - Sequence 250986 from Patent EP1572962.
JD487515 - Sequence 468539 from Patent EP1572962.
JD493689 - Sequence 474713 from Patent EP1572962.
JD372469 - Sequence 353493 from Patent EP1572962.
BC040711 - Homo sapiens, clone IMAGE:6025566, mRNA.
JD056296 - Sequence 37320 from Patent EP1572962.
JD159381 - Sequence 140405 from Patent EP1572962.
JD476252 - Sequence 457276 from Patent EP1572962.
JD417893 - Sequence 398917 from Patent EP1572962.
JD388020 - Sequence 369044 from Patent EP1572962.
JD459028 - Sequence 440052 from Patent EP1572962.
JD104116 - Sequence 85140 from Patent EP1572962.
JD334321 - Sequence 315345 from Patent EP1572962.
JD287009 - Sequence 268033 from Patent EP1572962.
JD547888 - Sequence 528912 from Patent EP1572962.
JD228246 - Sequence 209270 from Patent EP1572962.
JD546082 - Sequence 527106 from Patent EP1572962.
JD287791 - Sequence 268815 from Patent EP1572962.
JD334569 - Sequence 315593 from Patent EP1572962.
JD531353 - Sequence 512377 from Patent EP1572962.
JD432190 - Sequence 413214 from Patent EP1572962.
JD392082 - Sequence 373106 from Patent EP1572962.
JD156014 - Sequence 137038 from Patent EP1572962.
JD190888 - Sequence 171912 from Patent EP1572962.
JD343727 - Sequence 324751 from Patent EP1572962.
JD052122 - Sequence 33146 from Patent EP1572962.
JD559415 - Sequence 540439 from Patent EP1572962.
JD343470 - Sequence 324494 from Patent EP1572962.
JD423521 - Sequence 404545 from Patent EP1572962.
JD147661 - Sequence 128685 from Patent EP1572962.
JD435117 - Sequence 416141 from Patent EP1572962.
JD203906 - Sequence 184930 from Patent EP1572962.
JD174036 - Sequence 155060 from Patent EP1572962.
JD527123 - Sequence 508147 from Patent EP1572962.
JD400457 - Sequence 381481 from Patent EP1572962.
JD110121 - Sequence 91145 from Patent EP1572962.
JD554738 - Sequence 535762 from Patent EP1572962.
JD182864 - Sequence 163888 from Patent EP1572962.
JD142909 - Sequence 123933 from Patent EP1572962.
JD364175 - Sequence 345199 from Patent EP1572962.
JD141598 - Sequence 122622 from Patent EP1572962.
JD473482 - Sequence 454506 from Patent EP1572962.
JD054599 - Sequence 35623 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P30989 (Reactome details) participates in the following event(s):

R-HSA-388900 Neurotensin receptors can bind neurotensins
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000370501.1, ENST00000370501.2, ENST00000370501.3, NM_002531, NTR1_HUMAN, NTRR, P30989, Q9H4H1, Q9H4T5, uc002ydf.1, uc002ydf.2, uc002ydf.3, uc002ydf.4
UCSC ID: ENST00000370501.4
RefSeq Accession: NM_002531
Protein: P30989 (aka NTR1_HUMAN)
CCDS: CCDS13502.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.