ID:NTR1_HUMAN DESCRIPTION: RecName: Full=Neurotensin receptor type 1; Short=NT-R-1; Short=NTR1; AltName: Full=High-affinity levocabastine-insensitive neurotensin receptor; AltName: Full=NTRH; FUNCTION: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily. WEB RESOURCE: Name=Wikipedia; Note=Neurotensin receptor entry; URL="http://en.wikipedia.org/wiki/Neurotensin_receptor";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30989
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001659 temperature homeostasis GO:0003085 negative regulation of systemic arterial blood pressure GO:0003254 regulation of membrane depolarization GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007218 neuropeptide signaling pathway GO:0007268 chemical synaptic transmission GO:0007612 learning GO:0008344 adult locomotory behavior GO:0014049 positive regulation of glutamate secretion GO:0014054 positive regulation of gamma-aminobutyric acid secretion GO:0033993 response to lipid GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043576 regulation of respiratory gaseous exchange GO:0050965 detection of temperature stimulus involved in sensory perception of pain GO:0051280 negative regulation of release of sequestered calcium ion into cytosol GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0051930 regulation of sensory perception of pain GO:0060732 positive regulation of inositol phosphate biosynthetic process GO:0070779 D-aspartate import GO:0071545 inositol phosphate catabolic process GO:0090238 positive regulation of arachidonic acid secretion GO:0097151 positive regulation of inhibitory postsynaptic potential GO:0098712 L-glutamate import across plasma membrane GO:0098900 regulation of action potential GO:2001259 positive regulation of cation channel activity