Human Gene SERPINB2 (ENST00000299502.9) Description and Page Index
  Description: Homo sapiens serpin family B member 2 (SERPINB2), transcript variant 2, mRNA. (from RefSeq NM_002575)
Gencode Transcript: ENST00000299502.9
Gencode Gene: ENSG00000197632.9
Transcript (Including UTRs)
   Position: hg38 chr18:63,887,705-63,903,888 Size: 16,184 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg38 chr18:63,891,445-63,903,305 Size: 11,861 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:63,887,705-63,903,888)mRNA (may differ from genome)Protein (415 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PAI2_HUMAN
DESCRIPTION: RecName: Full=Plasminogen activator inhibitor 2; Short=PAI-2; AltName: Full=Monocyte Arg-serpin; AltName: Full=Placental plasminogen activator inhibitor; AltName: Full=Serpin B2; AltName: Full=Urokinase inhibitor; Flags: Precursor;
FUNCTION: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1.
SUBUNIT: Interacts with PSMB1.
SUBCELLULAR LOCATION: Cytoplasm. Secreted, extracellular space.
PTM: The signal sequence is not cleaved.
SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.

-  MalaCards Disease Associations
  MalaCards Gene Search: SERPINB2
Diseases sorted by gene-association score: lipodermatosclerosis (17), gingivitis (14), placenta accreta (11), ovarian cyst (9), joint disorders (8), adult respiratory distress syndrome (7), endometrial cancer (3), preeclampsia/eclampsia 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.01 RPKM in Esophagus - Mucosa
Total median expression: 38.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.3075-0.124 Picture PostScript Text
3' UTR -107.10583-0.184 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023795 - Protease_inhib_I4_serpin_CS
IPR015556 - Protease_inhib_serine_PAI-2
IPR023796 - Serpin_dom
IPR000215 - Serpin_fam

Pfam Domains:
PF00079 - Serpin (serine protease inhibitor)

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1BY7
- X-ray MuPIT

1JRR
- X-ray MuPIT

2ARQ
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
2ARR - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P05120
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity

Biological Process:
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0035722 interleukin-12-mediated signaling pathway
GO:0042060 wound healing
GO:0042730 fibrinolysis
GO:0043066 negative regulation of apoptotic process

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  KJ897293 - Synthetic construct Homo sapiens clone ccsbBroadEn_06687 SERPINB2 gene, encodes complete protein.
AK313159 - Homo sapiens cDNA, FLJ93654, highly similar to Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2), mRNA.
BC012609 - Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 2, mRNA (cDNA clone MGC:13616 IMAGE:4281085), complete cds.
LP895366 - Sequence 230 from Patent EP3253886.
Y00630 - Human mRNA for Arg-Serpin (plasminogen activator-inhibitor 2, PAI-2).
JD524593 - Sequence 505617 from Patent EP1572962.
J02685 - Human placental plasminogen activator inhibitor mRNA, complete cds.
A21238 - H.sapiens BTA 1445 mRNA for Pai-2.
J03603 - Human plasminogen activator inhibitor mRNA, complete cds.
A32415 - H.sapiens PAI-2 cDNA in pDBP1.
JD324333 - Sequence 305357 from Patent EP1572962.
M18082 - Human plasminogen activator inhibitor 2 (PAI-2) mRNA, complete cds.
DQ656059 - Homo sapiens clone UGL299-E-A6, mRNA sequence.
A21239 - H.sapiens BTA 1916 mRNA for Pai-2.
A21240 - H.sapiens BTA 1922 mRNA for Pai-2.
AB527561 - Synthetic construct DNA, clone: pF1KB6627, Homo sapiens SERPINB2 gene for serpin peptidase inhibitor, clade B (ovalbumin), member 2, without stop codon, in Flexi system.
DQ896116 - Synthetic construct Homo sapiens clone IMAGE:100010576; FLH190436.01L; RZPDo839A0566D serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2) gene, encodes complete protein.
DQ892867 - Synthetic construct clone IMAGE:100005497; FLH190440.01X; RZPDo839A0576D serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2) gene, encodes complete protein.
A21254 - H.sapiens PAI-2 mRNA.
JD024914 - Sequence 5938 from Patent EP1572962.
JD030344 - Sequence 11368 from Patent EP1572962.
JD300176 - Sequence 281200 from Patent EP1572962.
JD565853 - Sequence 546877 from Patent EP1572962.
JD349820 - Sequence 330844 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_fibrinolysisPathway - Fibrinolysis Pathway

Reactome (by CSHL, EBI, and GO)

Protein P05120 (Reactome details) participates in the following event(s):

R-HSA-159001 urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR
R-HSA-75205 Dissolution of Fibrin Clot
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-109582 Hemostasis
R-HSA-9020591 Interleukin-12 signaling
R-HSA-447115 Interleukin-12 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: NM_002575, P05120, PAI2, PAI2_HUMAN, PLANH2, Q96E96, uc002ljo.1, uc002ljo.2, uc002ljo.3, uc002ljo.4, uc002ljo.5
UCSC ID: uc002ljo.5
RefSeq Accession: NM_002575
Protein: P05120 (aka PAI2_HUMAN)
CCDS: CCDS11989.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.