Human Gene SERPINB2 (ENST00000299502.9) Description and Page Index
Description: Homo sapiens serpin family B member 2 (SERPINB2), transcript variant 2, mRNA. (from RefSeq NM_002575)
Gencode Transcript: ENST00000299502.9
Gencode Gene: ENSG00000197632.9
Transcript (Including UTRs)
Position: hg38 chr18:63,887,705-63,903,888 Size: 16,184 Total Exon Count: 8 Strand: +
Position: hg38 chr18:63,891,445-63,903,305 Size: 11,861 Coding Exon Count: 7
Data last updated: 2019-09-04
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Plasminogen activator inhibitor 2; Short=PAI-2; AltName: Full=Monocyte Arg-serpin; AltName: Full=Placental plasminogen activator inhibitor; AltName: Full=Serpin B2; AltName: Full=Urokinase inhibitor; Flags: Precursor;
FUNCTION: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1. SUBUNIT: Interacts with PSMB1. SUBCELLULAR LOCATION: Cytoplasm. Secreted, extracellular space. PTM: The signal sequence is not cleaved. SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR023795 - Protease_inhib_I4_serpin_CS
IPR015556 - Protease_inhib_serine_PAI-2
IPR023796 - Serpin_dom
IPR000215 - Serpin_fam
Pfam Domains: PF00079 - Serpin (serine protease inhibitor)
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P05120
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
KJ897293 - Synthetic construct Homo sapiens clone ccsbBroadEn_06687 SERPINB2 gene, encodes complete protein. AK313159 - Homo sapiens cDNA, FLJ93654, highly similar to Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2), mRNA. BC012609 - Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 2, mRNA (cDNA clone MGC:13616 IMAGE:4281085), complete cds. LP895366 - Sequence 230 from Patent EP3253886. Y00630 - Human mRNA for Arg-Serpin (plasminogen activator-inhibitor 2, PAI-2). JD524593 - Sequence 505617 from Patent EP1572962. J02685 - Human placental plasminogen activator inhibitor mRNA, complete cds. A21238 - H.sapiens BTA 1445 mRNA for Pai-2. J03603 - Human plasminogen activator inhibitor mRNA, complete cds. A32415 - H.sapiens PAI-2 cDNA in pDBP1. JD324333 - Sequence 305357 from Patent EP1572962. M18082 - Human plasminogen activator inhibitor 2 (PAI-2) mRNA, complete cds. DQ656059 - Homo sapiens clone UGL299-E-A6, mRNA sequence. A21239 - H.sapiens BTA 1916 mRNA for Pai-2. A21240 - H.sapiens BTA 1922 mRNA for Pai-2. AB527561 - Synthetic construct DNA, clone: pF1KB6627, Homo sapiens SERPINB2 gene for serpin peptidase inhibitor, clade B (ovalbumin), member 2, without stop codon, in Flexi system. DQ896116 - Synthetic construct Homo sapiens clone IMAGE:100010576; FLH190436.01L; RZPDo839A0566D serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2) gene, encodes complete protein. DQ892867 - Synthetic construct clone IMAGE:100005497; FLH190440.01X; RZPDo839A0576D serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2) gene, encodes complete protein. A21254 - H.sapiens PAI-2 mRNA. JD024914 - Sequence 5938 from Patent EP1572962. JD030344 - Sequence 11368 from Patent EP1572962. JD300176 - Sequence 281200 from Patent EP1572962. JD565853 - Sequence 546877 from Patent EP1572962. JD349820 - Sequence 330844 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: NM_002575, P05120, PAI2, PAI2_HUMAN, PLANH2, Q96E96, uc002ljo.1, uc002ljo.2, uc002ljo.3, uc002ljo.4, uc002ljo.5 UCSC ID: uc002ljo.5 RefSeq Accession: NM_002575
(aka PAI2_HUMAN) P05120
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.