Human Gene PPY (ENST00000225992.8) from GENCODE V36
Description: Homo sapiens pancreatic polypeptide (PPY), transcript variant 1, mRNA. (from RefSeq NM_002722) RefSeq Summary (NM_002722): This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]. Gencode Transcript: ENST00000225992.8 Gencode Gene: ENSG00000108849.8 Transcript (Including UTRs) Position: hg38 chr17:43,940,804-43,942,476 Size: 1,673 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr17:43,940,928-43,941,654 Size: 727 Coding Exon Count: 3
ID:PAHO_HUMAN DESCRIPTION: RecName: Full=Pancreatic prohormone; AltName: Full=Pancreatic polypeptide; Short=PP; AltName: INN=Obinepitide; Contains: RecName: Full=Pancreatic hormone; Short=PH; Contains: RecName: Full=Pancreatic icosapeptide; Short=PI; Flags: Precursor; FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. FUNCTION: The physiological role for the icosapeptide has not yet been elucidated. SUBCELLULAR LOCATION: Secreted. PHARMACEUTICAL: Obinepitide is under clinical trial by 7TM Pharma to be used for the treatment of obesity. Obinepitide is derived from pancreatic hormone by having Gln-63. SIMILARITY: Belongs to the NPY family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01298
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.