Description: Homo sapiens solute carrier family 18 member A1 (SLC18A1), transcript variant 2, mRNA. (from RefSeq NM_003053) RefSeq Summary (NM_003053): The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]. Gencode Transcript: ENST00000276373.10 Gencode Gene: ENSG00000036565.15 Transcript (Including UTRs) Position: hg38 chr8:20,144,855-20,183,136 Size: 38,282 Total Exon Count: 16 Strand: - Coding Region Position: hg38 chr8:20,145,763-20,180,964 Size: 35,202 Coding Exon Count: 15
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07690 - Major Facilitator Superfamily
ModBase Predicted Comparative 3D Structure on P54219
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.