Description: Homo sapiens tachykinin precursor 1 (TAC1), transcript variant beta, mRNA. (from RefSeq NM_003182) RefSeq Summary (NM_003182): This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]. Gencode Transcript: ENST00000319273.10 Gencode Gene: ENSG00000006128.12 Transcript (Including UTRs) Position: hg38 chr7:97,732,086-97,740,472 Size: 8,387 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr7:97,732,613-97,739,920 Size: 7,308 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20366
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.