Human Gene PYY (ENST00000360085.6)
  Description: Homo sapiens peptide YY (PYY), mRNA. (from RefSeq NM_004160)
RefSeq Summary (NM_004160): This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016].
Gencode Transcript: ENST00000360085.6
Gencode Gene: ENSG00000131096.10
Transcript (Including UTRs)
   Position: hg38 chr17:43,952,738-44,004,469 Size: 51,732 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr17:43,952,956-43,953,483 Size: 528 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:43,952,738-44,004,469)mRNA (may differ from genome)Protein (97 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PYY_HUMAN
DESCRIPTION: RecName: Full=Peptide YY; Short=PYY; AltName: Full=PYY-I; AltName: Full=Peptide tyrosine tyrosine; Contains: RecName: Full=Peptide YY(3-36); AltName: Full=PYY-II; Flags: Precursor;
FUNCTION: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the NPY family.

-  MalaCards Disease Associations
  MalaCards Gene Search: PYY
Diseases sorted by gene-association score: obesity, pyy-related* (100), anorexia nervosa (31), bulimia nervosa (26), short bowel syndrome (21), eating disorder (18), dumping syndrome (16), lymphocytic colitis (15), pneumatosis cystoides intestinalis (14), constipation (10), obesity (10), morbid obesity (10), duodenogastric reflux (9), prader-willi syndrome (9), gastroesophageal reflux (8), gastrointestinal system disease (7), postgastrectomy syndrome (6), carcinoid syndrome (6), irritable bowel syndrome (6), serotonin syndrome (4), overnutrition (4), diabetes mellitus, noninsulin-dependent (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.17 RPKM in Colon - Transverse
Total median expression: 51.11 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -174.10541-0.322 Picture PostScript Text
3' UTR -88.10218-0.404 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001955 - Pancreatic_hormone-like
IPR020392 - Pancreatic_hormone-like_CS

Pfam Domains:
PF00159 - Pancreatic hormone peptide

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2DEZ
- NMR

2DF0
- NMR

2L60
- NMR


ModBase Predicted Comparative 3D Structure on P10082
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001664 G-protein coupled receptor binding
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding

Biological Process:
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007631 feeding behavior
GO:0008283 cell proliferation
GO:0010469 regulation of receptor activity
GO:0032098 regulation of appetite

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  LF212459 - JP 2014500723-A/19962: Polycomb-Associated Non-Coding RNAs.
MA448036 - JP 2018138019-A/19962: Polycomb-Associated Non-Coding RNAs.
BC041057 - Homo sapiens peptide YY, mRNA (cDNA clone MGC:52233 IMAGE:5441270), complete cds.
D13902 - Homo sapiens mRNA for peptide YY, complete cds.
D13899 - Homo sapiens mRNA for peptide YY, complete cds.
JD218389 - Sequence 199413 from Patent EP1572962.
JD128769 - Sequence 109793 from Patent EP1572962.
JD389824 - Sequence 370848 from Patent EP1572962.
JD140227 - Sequence 121251 from Patent EP1572962.
JD083852 - Sequence 64876 from Patent EP1572962.
KJ901672 - Synthetic construct Homo sapiens clone ccsbBroadEn_11066 PYY gene, encodes complete protein.
KR712026 - Synthetic construct Homo sapiens clone CCSBHm_00034793 PYY (PYY) mRNA, encodes complete protein.
KR712027 - Synthetic construct Homo sapiens clone CCSBHm_00034794 PYY (PYY) mRNA, encodes complete protein.
CR542129 - Homo sapiens full open reading frame cDNA clone RZPDo834D1023D for gene PYY, peptide YY; complete cds, incl. stopcodon.
JD254178 - Sequence 235202 from Patent EP1572962.
JD391957 - Sequence 372981 from Patent EP1572962.
JD165390 - Sequence 146414 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P10082 (Reactome details) participates in the following event(s):

R-HSA-388863 Neuropeptide Y receptors can bind neuropeptide Y-related peptides
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000360085.1, ENST00000360085.2, ENST00000360085.3, ENST00000360085.4, ENST00000360085.5, NM_004160, P10082, PYY_HUMAN, Q5U5Q6, Q6FGH8, uc002ieq.1, uc002ieq.2, uc002ieq.3, uc002ieq.4
UCSC ID: ENST00000360085.6
RefSeq Accession: NM_004160
Protein: P10082 (aka PYY_HUMAN)
CCDS: CCDS32662.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.