Human Gene NPBWR2 (ENST00000369768.1)
  Description: Homo sapiens neuropeptides B and W receptor 2 (NPBWR2), mRNA. (from RefSeq NM_005286)
Gencode Transcript: ENST00000369768.1
Gencode Gene: ENSG00000125522.3
Transcript (Including UTRs)
   Position: hg38 chr20:64,105,820-64,107,171 Size: 1,352 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg38 chr20:64,105,830-64,106,831 Size: 1,002 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr20:64,105,820-64,107,171)mRNA (may differ from genome)Protein (333 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Neuropeptides B/W receptor type 2; AltName: Full=G-protein coupled receptor 8;
FUNCTION: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Detected at high levels in caudate nucleus, hyppocampus and amygdala; at moderate levels in the adult brain, thalamus, parietal cortex, pituitary gland, adrenal gland and lymph nodes.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.25 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 0.58 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -128.30340-0.377 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR009150 - Neuropept_W_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P48146
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein Sequence     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004985 opioid receptor activity
GO:0005515 protein binding
GO:0008188 neuropeptide receptor activity
GO:0042923 neuropeptide binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0038003 opioid receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection

-  Descriptions from all associated GenBank mRNAs
  BC067481 - Homo sapiens neuropeptides B/W receptor 2, mRNA (cDNA clone MGC:79315 IMAGE:6971825), complete cds.
BC067482 - Homo sapiens neuropeptides B/W receptor 2, mRNA (cDNA clone MGC:79316 IMAGE:6971826), complete cds.
BC067483 - Homo sapiens neuropeptides B/W receptor 2, mRNA (cDNA clone MGC:79317 IMAGE:6971827), complete cds.
HQ447590 - Synthetic construct Homo sapiens clone IMAGE:100070933; CCSB014595_01 neuropeptides B/W receptor 2 (NPBWR2) gene, encodes complete protein.
KJ896914 - Synthetic construct Homo sapiens clone ccsbBroadEn_06308 NPBWR2 gene, encodes complete protein.
KJ905763 - Synthetic construct Homo sapiens clone ccsbBroadEn_15433 NPBWR2 gene, encodes complete protein.
CU688306 - Synthetic construct Homo sapiens gateway clone IMAGE:100022908 5' read NPBWR2 mRNA.
CU688304 - Synthetic construct Homo sapiens gateway clone IMAGE:100022890 5' read NPBWR2 mRNA.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P48146 (Reactome details) participates in the following event(s):

R-HSA-374787 GPCR neuropeptide receptor binds neuropeptides B and W
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: GPR8, NM_005286, NPBW2_HUMAN, P48146, Q6NWQ6, Q9H4K3, uc011abt.1, uc011abt.2, uc011abt.3
UCSC ID: ENST00000369768.1
Representative RNA: NM_005286
Protein: P48146 (aka NPBW2_HUMAN)
CCDS: CCDS13557.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.