Human Gene HTR3B (ENST00000260191.8) from GENCODE V44
Description: Homo sapiens 5-hydroxytryptamine receptor 3B (HTR3B), transcript variant 1, mRNA. (from RefSeq NM_006028) RefSeq Summary (NM_006028): The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000260191.8 Gencode Gene: ENSG00000149305.8 Transcript (Including UTRs) Position: hg38 chr11:113,904,796-113,949,079 Size: 44,284 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr11:113,904,934-113,946,137 Size: 41,204 Coding Exon Count: 9
ID:5HT3B_HUMAN DESCRIPTION: RecName: Full=5-hydroxytryptamine receptor 3B; Short=5-HT3-B; Short=5-HT3B; AltName: Full=Serotonin receptor 3B; Flags: Precursor; FUNCTION: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. SUBUNIT: Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. TISSUE SPECIFICITY: Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta. PTM: N-glycosylation required for membrane localization. MISCELLANEOUS: The HA-stretch region of HTR3B seems to confer increased conductance to HTR3A/HTR3B heteromers compared to that of HTR3A homomers. SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95264
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004888 transmembrane signaling receptor activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0015276 ligand-gated ion channel activity GO:0022850 serotonin-gated cation channel activity
Biological Process: GO:0006811 ion transport GO:0007165 signal transduction GO:0007210 serotonin receptor signaling pathway GO:0034220 ion transmembrane transport
AK314268 - Homo sapiens cDNA, FLJ95021, Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3B (HTR3B),mRNA. AF169255 - Homo sapiens 5-hydroxytryptamine 3 receptor B subunit (5-HTR3B) mRNA, complete cds. AF080582 - Homo sapiens 5-hydroxytryptamine 3 receptor B subunit precursor, mRNA, complete cds. JD298397 - Sequence 279421 from Patent EP1572962. JD482224 - Sequence 463248 from Patent EP1572962. AB463385 - Synthetic construct DNA, clone: pF1KB7256, Homo sapiens HTR3B gene for 5-hydroxytryptamine (serotonin) receptor 3B, without stop codon, in Flexi system. BC141515 - Synthetic construct Homo sapiens clone IMAGE:100014568, MGC:175314 5-hydroxytryptamine (serotonin) receptor 3B (HTR3B) mRNA, encodes complete protein. AM293589 - Homo sapiens mRNA for 5-hydroxytryptamine receptor 3 subunit B (HTR3B gene). JD185763 - Sequence 166787 from Patent EP1572962. JD364473 - Sequence 345497 from Patent EP1572962. JD097404 - Sequence 78428 from Patent EP1572962. JD350934 - Sequence 331958 from Patent EP1572962. JD364475 - Sequence 345499 from Patent EP1572962. JD512484 - Sequence 493508 from Patent EP1572962. JD545033 - Sequence 526057 from Patent EP1572962. JD220458 - Sequence 201482 from Patent EP1572962. JD135689 - Sequence 116713 from Patent EP1572962. JD423116 - Sequence 404140 from Patent EP1572962. JD537923 - Sequence 518947 from Patent EP1572962. JD461424 - Sequence 442448 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O95264 (Reactome details) participates in the following event(s):
R-HSA-975311 HTR3 pentamer:5HT transports Na+,K+, and Ca2+ R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System