Human Gene NMU (ENST00000264218.7)
  Description: Homo sapiens neuromedin U (NMU), transcript variant 1, mRNA. (from RefSeq NM_006681)
RefSeq Summary (NM_006681): This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015].
Gencode Transcript: ENST00000264218.7
Gencode Gene: ENSG00000109255.11
Transcript (Including UTRs)
   Position: hg38 chr4:55,595,231-55,636,298 Size: 41,068 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr4:55,599,146-55,636,192 Size: 37,047 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:55,595,231-55,636,298)mRNA (may differ from genome)Protein (174 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Neuromedin-U; Contains: RecName: Full=Neuromedin-U-25; Short=NmU-25; Flags: Precursor;
FUNCTION: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.
TISSUE SPECIFICITY: Expressed throughout the enteric nervous system with highest levels being found in the jejunum.
SIMILARITY: Belongs to the NmU family.

-  MalaCards Disease Associations
  MalaCards Gene Search: NMU
Diseases sorted by gene-association score: squamous cell papilloma (7), seminal vesicle adenocarcinoma (7), trachea leiomyoma (6), miles-carpenter syndrome (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.17 RPKM in Esophagus - Mucosa
Total median expression: 97.20 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.90106-0.339 Picture PostScript Text
3' UTR -31.30185-0.169 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018070 - Neuromedin-U_amidation-site
IPR008200 - NMU_C

Pfam Domains:
PF02070 - Neuromedin U

ModBase Predicted Comparative 3D Structure on P48645
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0031839 type 1 neuromedin U receptor binding
GO:0031840 type 2 neuromedin U receptor binding
GO:0042922 neuromedin U receptor binding

Biological Process:
GO:0001659 temperature homeostasis
GO:0001696 gastric acid secretion
GO:0006940 regulation of smooth muscle contraction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0009648 photoperiodism
GO:0010460 positive regulation of heart rate
GO:0019233 sensory perception of pain
GO:0031652 positive regulation of heat generation
GO:0042755 eating behavior
GO:0044497 positive regulation of blood pressure in other organism
GO:0045187 regulation of circadian sleep/wake cycle, sleep
GO:0045987 positive regulation of smooth muscle contraction
GO:0046887 positive regulation of hormone secretion
GO:0050806 positive regulation of synaptic transmission
GO:0060259 regulation of feeding behavior
GO:0060455 negative regulation of gastric acid secretion
GO:0097009 energy homeostasis
GO:1902722 positive regulation of prolactin secretion
GO:1903999 negative regulation of eating behavior
GO:1904058 positive regulation of sensory perception of pain
GO:2000252 negative regulation of feeding behavior
GO:2000821 regulation of grooming behavior

Cellular Component:
GO:0005576 extracellular region
GO:0043195 terminal bouton

-  Descriptions from all associated GenBank mRNAs
  BC012908 - Homo sapiens neuromedin U, mRNA (cDNA clone MGC:8934 IMAGE:3864111), complete cds.
X76029 - H.sapiens mRNA for neuromedin U.
JD234845 - Sequence 215869 from Patent EP1572962.
JD197491 - Sequence 178515 from Patent EP1572962.
DQ891295 - Synthetic construct clone IMAGE:100003925; FLH170823.01X; RZPDo839B12100D neuromedin U (NMU) gene, encodes complete protein.
DQ894479 - Synthetic construct Homo sapiens clone IMAGE:100008939; FLH170819.01L; RZPDo839B1299D neuromedin U (NMU) gene, encodes complete protein.
AJ510135 - Homo sapiens partial mRNA for neuromedin U (NMU gene), 25E isoform.
AJ510133 - Homo sapiens partial mRNA for neuromedin U (NMU gene), 38C isoform.
AJ510134 - Homo sapiens partial mRNA for neuromedin U (NMU gene), 25D isoform.
AM279463 - Homo sapiens partial mRNA for neuromedin U precursor (NMU gene), 21B isoform.
JD497481 - Sequence 478505 from Patent EP1572962.
JD138895 - Sequence 119919 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P48645 (Reactome details) participates in the following event(s):

R-HSA-964800 Neuromedin-U receptors bind neuromedins U, S
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000264218.1, ENST00000264218.2, ENST00000264218.3, ENST00000264218.4, ENST00000264218.5, ENST00000264218.6, NMU_HUMAN, NM_006681, P48645, uc003hbc.1, uc003hbc.2, uc003hbc.3
UCSC ID: ENST00000264218.7
RefSeq Accession: NM_006681
Protein: P48645 (aka NMU_HUMAN)
CCDS: CCDS3501.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.