Description: Homo sapiens neuromedin U (NMU), transcript variant 1, mRNA. (from RefSeq NM_006681) RefSeq Summary (NM_006681): This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]. Gencode Transcript: ENST00000264218.7 Gencode Gene: ENSG00000109255.11 Transcript (Including UTRs) Position: hg38 chr4:55,595,231-55,636,298 Size: 41,068 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr4:55,599,146-55,636,192 Size: 37,047 Coding Exon Count: 9
ID:NMU_HUMAN DESCRIPTION: RecName: Full=Neuromedin-U; Contains: RecName: Full=Neuromedin-U-25; Short=NmU-25; Flags: Precursor; FUNCTION: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed throughout the enteric nervous system with highest levels being found in the jejunum. SIMILARITY: Belongs to the NmU family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48645
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.