Description: Homo sapiens neurotensin receptor 2 (NTSR2), mRNA. (from RefSeq NM_012344) RefSeq Summary (NM_012344): The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Gencode Transcript: ENST00000306928.6 Gencode Gene: ENSG00000169006.7 Transcript (Including UTRs) Position: hg38 chr2:11,658,178-11,670,195 Size: 12,018 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr2:11,658,479-11,670,129 Size: 11,651 Coding Exon Count: 4
ID:NTR2_HUMAN DESCRIPTION: RecName: Full=Neurotensin receptor type 2; Short=NT-R-2; Short=NTR2; AltName: Full=Levocabastine-sensitive neurotensin receptor; FUNCTION: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily. SEQUENCE CAUTION: Sequence=EAX00924.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Wikipedia; Note=Neurotensin receptor entry; URL="http://en.wikipedia.org/wiki/Neurotensin_receptor";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95665
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.