Human Gene NTSR2 (ENST00000306928.6)
  Description: Homo sapiens neurotensin receptor 2 (NTSR2), mRNA. (from RefSeq NM_012344)
RefSeq Summary (NM_012344): The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.
Gencode Transcript: ENST00000306928.6
Gencode Gene: ENSG00000169006.7
Transcript (Including UTRs)
   Position: hg38 chr2:11,658,178-11,670,195 Size: 12,018 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr2:11,658,479-11,670,129 Size: 11,651 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:11,658,178-11,670,195)mRNA (may differ from genome)Protein (410 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Neurotensin receptor type 2; Short=NT-R-2; Short=NTR2; AltName: Full=Levocabastine-sensitive neurotensin receptor;
FUNCTION: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.
SEQUENCE CAUTION: Sequence=EAX00924.1; Type=Erroneous gene model prediction;
WEB RESOURCE: Name=Wikipedia; Note=Neurotensin receptor entry; URL="";

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 62.63 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 371.11 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.9066-0.408 Picture PostScript Text
3' UTR -79.80301-0.265 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR003986 - NT2_rcpt
IPR003984 - NT_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on O95665
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0016492 G-protein coupled neurotensin receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007600 sensory perception
GO:0042391 regulation of membrane potential

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC037776 - Homo sapiens neurotensin receptor 2, mRNA (cDNA clone MGC:41842 IMAGE:4817029), complete cds.
Y10148 - H.sapiens mRNA for NTR2 receptor.
BC022501 - Homo sapiens neurotensin receptor 2, mRNA (cDNA clone MGC:26447 IMAGE:4792730), complete cds.
AY429107 - Homo sapiens neurotensin receptor 2 mRNA, complete cds.
DQ893289 - Synthetic construct clone IMAGE:100005919; FLH195995.01X; RZPDo839B04154D neurotensin receptor 2 (NTSR2) gene, encodes complete protein.
EU176212 - Synthetic construct Homo sapiens clone IMAGE:100006589; FLH263917.01X; RZPDo839D09246D neurotensin receptor 2 (NTSR2) gene, encodes complete protein.
EU176513 - Synthetic construct Homo sapiens clone IMAGE:100011625; FLH263923.01L; RZPDo839C11246D neurotensin receptor 2 (NTSR2) gene, encodes complete protein.
EU176803 - Synthetic construct Homo sapiens clone IMAGE:100011614; FLH263892.01L; RZPDo839D09247D neurotensin receptor 2 (NTSR2) gene, encodes complete protein.
JD345472 - Sequence 326496 from Patent EP1572962.
JD266184 - Sequence 247208 from Patent EP1572962.
JD233671 - Sequence 214695 from Patent EP1572962.
JD365515 - Sequence 346539 from Patent EP1572962.
JD058243 - Sequence 39267 from Patent EP1572962.
JD116676 - Sequence 97700 from Patent EP1572962.
JD087899 - Sequence 68923 from Patent EP1572962.
JD089786 - Sequence 70810 from Patent EP1572962.
JD520660 - Sequence 501684 from Patent EP1572962.
JD464912 - Sequence 445936 from Patent EP1572962.
JD474876 - Sequence 455900 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein O95665 (Reactome details) participates in the following event(s):

R-HSA-388900 Neurotensin receptors can bind neurotensins
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000306928.1, ENST00000306928.2, ENST00000306928.3, ENST00000306928.4, ENST00000306928.5, NM_012344, NTR2_HUMAN, O95665, Q53QQ5, Q57Z87, Q8IY58, Q8TBH6, uc002rbq.1, uc002rbq.2, uc002rbq.3, uc002rbq.4, uc002rbq.5, uc002rbq.6
UCSC ID: ENST00000306928.6
RefSeq Accession: NM_012344
Protein: O95665 (aka NTR2_HUMAN)
CCDS: CCDS1681.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.