Human Gene NPFFR1 (ENST00000277942.7)
  Description: Homo sapiens neuropeptide FF receptor 1 (NPFFR1), mRNA. (from RefSeq NM_022146)
Gencode Transcript: ENST00000277942.7
Gencode Gene: ENSG00000148734.8
Transcript (Including UTRs)
   Position: hg38 chr10:70,247,329-70,284,004 Size: 36,676 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr10:70,254,957-70,283,676 Size: 28,720 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:70,247,329-70,284,004)mRNA (may differ from genome)Protein (430 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Neuropeptide FF receptor 1; AltName: Full=G-protein coupled receptor 147; AltName: Full=RFamide-related peptide receptor OT7T022;
FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=BAC05950.1; Type=Erroneous gene model prediction;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.62 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 18.98 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -176.20328-0.537 Picture PostScript Text
3' UTR -2693.707628-0.353 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR005395 - NPFF_rcpt
IPR005396 - NPFF_rcpt_1

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on Q9GZQ6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0008188 neuropeptide receptor activity
GO:0042277 peptide binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0008150 biological_process
GO:0032870 cellular response to hormone stimulus
GO:1901652 response to peptide

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  LF356039 - JP 2014500723-A/163542: Polycomb-Associated Non-Coding RNAs.
MA591616 - JP 2018138019-A/163542: Polycomb-Associated Non-Coding RNAs.
LP917458 - Sequence 54 from Patent WO2017153710.
LQ844134 - Sequence 54 from Patent WO2018138468.
JD401740 - Sequence 382764 from Patent EP1572962.
JD401741 - Sequence 382765 from Patent EP1572962.
JD344241 - Sequence 325265 from Patent EP1572962.
JD346465 - Sequence 327489 from Patent EP1572962.
JD311979 - Sequence 293003 from Patent EP1572962.
JD095439 - Sequence 76463 from Patent EP1572962.
JD213184 - Sequence 194208 from Patent EP1572962.
JD533913 - Sequence 514937 from Patent EP1572962.
JD407612 - Sequence 388636 from Patent EP1572962.
JD152283 - Sequence 133307 from Patent EP1572962.
JD399336 - Sequence 380360 from Patent EP1572962.
JD213183 - Sequence 194207 from Patent EP1572962.
JD177518 - Sequence 158542 from Patent EP1572962.
JD177519 - Sequence 158543 from Patent EP1572962.
JD322957 - Sequence 303981 from Patent EP1572962.
JD307079 - Sequence 288103 from Patent EP1572962.
JD434905 - Sequence 415929 from Patent EP1572962.
JD529700 - Sequence 510724 from Patent EP1572962.
JD173106 - Sequence 154130 from Patent EP1572962.
JD203434 - Sequence 184458 from Patent EP1572962.
JD539871 - Sequence 520895 from Patent EP1572962.
JD430468 - Sequence 411492 from Patent EP1572962.
JD395428 - Sequence 376452 from Patent EP1572962.
JD277274 - Sequence 258298 from Patent EP1572962.
JD425060 - Sequence 406084 from Patent EP1572962.
JD165408 - Sequence 146432 from Patent EP1572962.
JD401615 - Sequence 382639 from Patent EP1572962.
MP272075 - Sequence 23 from Patent WO2019157381.
AB040104 - Homo sapiens OT7T022 mRNA for RFamide-related peptide receptor, complete cds.
AF268898 - Homo sapiens neuropeptide FF receptor 1 (NPFF1) mRNA, complete cds.
AF330055 - Homo sapiens neuropeptide NPVF receptor mRNA, complete cds.
BC131580 - Homo sapiens neuropeptide FF receptor 1, mRNA (cDNA clone MGC:149215 IMAGE:40112416), complete cds.
EU432128 - Homo sapiens neuropeptide FF receptor 1 (NPFFR1) mRNA, complete cds.
KJ899440 - Synthetic construct Homo sapiens clone ccsbBroadEn_08834 NPFFR1 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein Q9GZQ6 (Reactome details) participates in the following event(s):

R-HSA-389491 Two NPFF receptors can bind neuropeptide FF
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A2RRF0, ENST00000277942.1, ENST00000277942.2, ENST00000277942.3, ENST00000277942.4, ENST00000277942.5, ENST00000277942.6, GPR147, NM_022146, NPFF1, NPFF1_HUMAN, Q8NGR0, Q96RN3, Q9GZQ6, uc021psj.1, uc021psj.2, uc021psj.3
UCSC ID: ENST00000277942.7
RefSeq Accession: NM_022146
Protein: Q9GZQ6 (aka NPFF1_HUMAN or NFF1_HUMAN)
CCDS: CCDS53539.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.