Human Gene INA (ENST00000369849.9) from GENCODE V44
Description: Homo sapiens internexin neuronal intermediate filament protein alpha (INA), mRNA. (from RefSeq NM_032727) RefSeq Summary (NM_032727): Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]. Gencode Transcript: ENST00000369849.9 Gencode Gene: ENSG00000148798.11 Transcript (Including UTRs) Position: hg38 chr10:103,277,138-103,290,346 Size: 13,209 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr10:103,277,212-103,288,669 Size: 11,458 Coding Exon Count: 3
ID:AINX_HUMAN DESCRIPTION: RecName: Full=Alpha-internexin; Short=Alpha-Inx; AltName: Full=66 kDa neurofilament protein; Short=NF-66; Short=Neurofilament-66; AltName: Full=Neurofilament 5; FUNCTION: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. TISSUE SPECIFICITY: Found predominantly in adult CNS. DEVELOPMENTAL STAGE: Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation. PTM: O-glycosylated (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the intermediate filament family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00038 - Intermediate filament protein PF04732 - Intermediate filament head (DNA binding) region
ModBase Predicted Comparative 3D Structure on Q16352
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.