Human Gene PANX2 (ENST00000395842.3) from GENCODE V39

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Description: Homo sapiens pannexin 2 (PANX2), transcript variant 1, mRNA. (from RefSeq NM_052839)
RefSeq Summary (NM_052839): The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Gencode Transcript: ENST00000395842.3
Gencode Gene: ENSG00000073150.14
Transcript (Including UTRs)
Position: hg38 chr22:50,170,731-50,180,295 Size: 9,565 Total Exon Count: 3 Strand: +
Coding Region
Position: hg38 chr22:50,170,731-50,179,277 Size: 8,547 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	CTD	RNA-Seq Expression	Microarray Expression
RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions	Pathways
Other Names	Methods

Data last updated at UCSC: 2022-01-17 08:30:34

Sequence and Links to Tools and Databases

Genomic Sequence (chr22:50,170,731-50,180,295)			mRNA (may differ from genome)		Protein (677 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	BioGPS
CGAP	Ensembl	Entrez Gene	ExonPrimer	Gencode	GeneCards
HGNC	HPRD	Lynx	MGI	neXtProt	OMIM
PubMed	Reactome	UniProtKB

Comments and Description Text from UniProtKB


	ID: PANX2_HUMAN DESCRIPTION: RecName: Full=Pannexin-2; FUNCTION: Structural component of the gap junctions and the hemichannels (By similarity). SUBUNIT: Forms PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes. Does not form homomeric channels (By similarity). INTERACTION: P62993:GRB2; NbExp=1; IntAct=EBI-1759592, EBI-401755; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential). Cell junction, gap junction. SIMILARITY: Belongs to the pannexin family. WEB RESOURCE: Name=Wikipedia; Note=Pannexin entry; URL="http://en.wikipedia.org/wiki/Pannexin";

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C029141 2,2,5,7,8-pentamethyl-1-hydroxychroman C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C035208 2-amino-4,6-dinitrotoluene C035207 4-amino-2,6-dinitrotoluene D000082 Acetaminophen D003300 Copper D004052 Diethylnitrosamine C558013 NSC 689534 D013749 Tetrachlorodibenzodioxin more ... click here to view the complete list

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 35.40 RPKM in Brain - Cerebellum Total median expression: 291.43 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-458.20	1018	-0.450	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000990 - Innexin

Pfam Domains:
PF00876 - Innexin

ModBase Predicted Comparative 3D Structure on Q96RD6


Front	Top	Side

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Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	Genome Browser	No ortholog	Genome Browser	No ortholog
Gene Details
Gene Sorter
MGI	RGD	Ensembl		WormBase
Protein Sequence	Protein Sequence	Protein Sequence		Protein Sequence
Alignment	Alignment	Alignment		Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0015267 channel activity GO:0022829 wide pore channel activity GO:0055077 gap junction hemi-channel activity Biological Process: GO:0002931 response to ischemia GO:0006811 ion transport GO:0006812 cation transport GO:0007267 cell-cell signaling GO:0034214 protein hexamerization GO:0055085 transmembrane transport Cellular Component: GO:0005737 cytoplasm GO:0005886 plasma membrane GO:0005921 gap junction GO:0012505 endomembrane system GO:0016020 membrane GO:0016021 integral component of membrane GO:0030054 cell junction

Descriptions from all associated GenBank mRNAs


	AK299910 - Homo sapiens cDNA FLJ61621 complete cds, highly similar to Pannexin-2. AK096019 - Homo sapiens cDNA FLJ38700 fis, clone KIDNE2002191, highly similar to Pannexin-2. AF398510 - Homo sapiens pannexin 2 isoform 1 (PANX2) mRNA, complete cds. AF398511 - Homo sapiens pannexin 2 isoform 2 (PANX2) mRNA, complete cds. BC101023 - Homo sapiens pannexin 2, mRNA (cDNA clone MGC:119432 IMAGE:40007400), complete cds. CR456467 - Homo sapiens dJ402G11.9 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ402G11.9.V2). AB463158 - Synthetic construct DNA, clone: pF1KB8716, Homo sapiens PANX2 gene for pannexin 2, without stop codon, in Flexi system. CU013305 - Homo sapiens PANX2, mRNA (cDNA clone IMAGE:100000083), complete cds, without stop codon, in Gateway system. CU013017 - Homo sapiens PANX2, mRNA (cDNA clone IMAGE:100000179), complete cds, with stop codon, in Gateway system. AK123508 - Homo sapiens cDNA FLJ41514 fis, clone BRTHA2010907. JD128905 - Sequence 109929 from Patent EP1572962. JD460230 - Sequence 441254 from Patent EP1572962. JD139942 - Sequence 120966 from Patent EP1572962. JD466631 - Sequence 447655 from Patent EP1572962. JD544616 - Sequence 525640 from Patent EP1572962. JD540596 - Sequence 521620 from Patent EP1572962. JD469100 - Sequence 450124 from Patent EP1572962. JD383711 - Sequence 364735 from Patent EP1572962. JD104941 - Sequence 85965 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q96RD6 (Reactome details) participates in the following event(s): R-HSA-375339 Pannexin 1/Pannexin2 mediated neuronal gap junction communication R-HSA-112303 Electric Transmission Across Gap Junctions R-HSA-112307 Transmission across Electrical Synapses R-HSA-112316 Neuronal System

Other Names for This Gene


	Alternate Gene Symbols: B7Z684, ENST00000395842.1, ENST00000395842.2, NM_052839, PANX2_HUMAN, Q96RD5, Q96RD6, Q9UGX8, uc003bjn.1, uc003bjn.2, uc003bjn.3, uc003bjn.4, uc003bjn.5, uc003bjn.6 UCSC ID: ENST00000395842.3 RefSeq Accession: NM_052839 Protein: Q96RD6 (aka PANX2_HUMAN or PAN2_HUMAN) CCDS: CCDS14085.2

Methods, Credits, and Use Restrictions


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