Human Gene PANX3 (ENST00000284288.3) from GENCODE V39
  Description: Homo sapiens pannexin 3 (PANX3), mRNA. (from RefSeq NM_052959)
RefSeq Summary (NM_052959): The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000284288.3
Gencode Gene: ENSG00000154143.3
Transcript (Including UTRs)
   Position: hg38 chr11:124,611,428-124,620,356 Size: 8,929 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr11:124,611,557-124,619,935 Size: 8,379 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2022-01-17 08:30:34

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:124,611,428-124,620,356)mRNA (may differ from genome)Protein (392 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: PANX3_HUMAN
DESCRIPTION: RecName: Full=Pannexin-3;
FUNCTION: Structural component of the gap junctions and the hemichannels.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential). Cell junction, gap junction.
SIMILARITY: Belongs to the pannexin family.
WEB RESOURCE: Name=Wikipedia; Note=Pannexin entry; URL="http://en.wikipedia.org/wiki/Pannexin";

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.39 RPKM in Testis
Total median expression: 1.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.80129-0.293 Picture PostScript Text
3' UTR -70.40421-0.167 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000990 - Innexin

Pfam Domains:
PF00876 - Innexin

ModBase Predicted Comparative 3D Structure on Q96QZ0
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0022829 wide pore channel activity
GO:0055077 gap junction hemi-channel activity

Biological Process:
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007267 cell-cell signaling
GO:0034214 protein hexamerization
GO:0055085 transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction


-  Descriptions from all associated GenBank mRNAs
  AB528788 - Synthetic construct DNA, clone: pF1KE0253, Homo sapiens PANX3 gene for pannexin 3, without stop codon, in Flexi system.
BC152944 - Synthetic construct Homo sapiens clone IMAGE:100016148, MGC:184213 pannexin 3 (PANX3) mRNA, encodes complete protein.
AF406650 - Homo sapiens putative gap junction protein pannexin 3 (PANX3) mRNA, complete cds.
JD042413 - Sequence 23437 from Patent EP1572962.
JD328487 - Sequence 309511 from Patent EP1572962.
JD496350 - Sequence 477374 from Patent EP1572962.
JD203009 - Sequence 184033 from Patent EP1572962.
JD516141 - Sequence 497165 from Patent EP1572962.
JD328857 - Sequence 309881 from Patent EP1572962.
JD423384 - Sequence 404408 from Patent EP1572962.
JD168046 - Sequence 149070 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000284288.1, ENST00000284288.2, NM_052959, PANX3_HUMAN, Q96QZ0, uc001qah.1, uc001qah.2, uc001qah.3, uc001qah.4, uc001qah.5
UCSC ID: ENST00000284288.3
RefSeq Accession: NM_052959
Protein: Q96QZ0 (aka PANX3_HUMAN or PAN3_HUMAN)
CCDS: CCDS8447.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.