Human Gene PTGS1 (ENST00000223423.8) from GENCODE V43
Description: Homo sapiens prostaglandin-endoperoxide synthase 1 (PTGS1), transcript variant 2, mRNA. (from RefSeq NM_080591) RefSeq Summary (NM_080591): This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Gencode Transcript: ENST00000223423.8 Gencode Gene: ENSG00000095303.17 Transcript (Including UTRs) Position: hg38 chr9:122,371,080-122,393,178 Size: 22,099 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr9:122,371,085-122,392,544 Size: 21,460 Coding Exon Count: 11
ID:PGH1_HUMAN DESCRIPTION: RecName: Full=Prostaglandin G/H synthase 1; EC=126.96.36.199; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; AltName: Full=Prostaglandin-endoperoxide synthase 1; Flags: Precursor; FUNCTION: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. CATALYTIC ACTIVITY: Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity). PATHWAY: Lipid metabolism; prostaglandin biosynthesis. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. MISCELLANEOUS: This enzyme acts both as a dioxygenase and as a peroxidase. MISCELLANEOUS: This enzyme is the target of nonsteroidal anti- inflammatory drugs such as aspirin. SIMILARITY: Belongs to the prostaglandin G/H synthase family. SIMILARITY: Contains 1 EGF-like domain. SEQUENCE CAUTION: Sequence=CAI14716.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ptgs1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23219
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.