ID:ACY3_HUMAN DESCRIPTION: RecName: Full=Aspartoacylase-2; EC=3.5.1.-; AltName: Full=Acylase III; AltName: Full=Aminoacylase-3; Short=ACY-3; AltName: Full=Hepatitis C virus core-binding protein 1; Short=HCBP1; Short=HCV core-binding protein 1; FUNCTION: Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity). COFACTOR: Binds 1 zinc ion per subunit (Potential). SUBUNIT: Homotetramer (By similarity). Interacts with HCV core protein. SUBCELLULAR LOCATION: Apical cell membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm. SIMILARITY: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04952 - Succinylglutamate desuccinylase / Aspartoacylase family
ModBase Predicted Comparative 3D Structure on Q96HD9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003674 molecular_function GO:0004046 aminoacylase activity GO:0005515 protein binding GO:0016787 hydrolase activity GO:0016788 hydrolase activity, acting on ester bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0042802 identical protein binding GO:0046872 metal ion binding
US Server
