Human Gene HTR3E (ENST00000335304.6) from GENCODE V44
Description: Homo sapiens 5-hydroxytryptamine receptor 3E (HTR3E), transcript variant 1, mRNA. (from RefSeq NM_182589) RefSeq Summary (NM_182589): This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]. Gencode Transcript: ENST00000335304.6 Gencode Gene: ENSG00000186038.9 Transcript (Including UTRs) Position: hg38 chr3:184,100,179-184,106,995 Size: 6,817 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr3:184,100,373-184,106,693 Size: 6,321 Coding Exon Count: 8
ID:5HT3E_HUMAN DESCRIPTION: RecName: Full=5-hydroxytryptamine receptor 3E; Short=5-HT3-E; Short=5-HT3E; AltName: Full=Serotonin receptor 3E; Flags: Precursor; FUNCTION: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. SUBUNIT: Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. TISSUE SPECIFICITY: Expressed in adult colon and intestine. SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A5X5Y0
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004888 transmembrane signaling receptor activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005515 protein binding GO:0022850 serotonin-gated cation channel activity
Biological Process: GO:0006811 ion transport GO:0007165 signal transduction GO:0007210 serotonin receptor signaling pathway GO:0034220 ion transmembrane transport
DQ644022 - Homo sapiens 5-HT3 receptor subunit E splice variant HTR3Ea mRNA, complete cds, alternatively spliced. AY349352 - Homo sapiens 5-HT3c1 serotonin receptor-like protein mRNA, complete cds; alternatively spliced. AY159813 - Homo sapiens 5-hydroxytryptamine serotonin receptor 3E (HTR3E) mRNA, complete cds. BC101182 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3, family member E, mRNA (cDNA clone MGC:120034 IMAGE:40017961), complete cds. BC101183 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3, family member E, mRNA (cDNA clone MGC:120035 IMAGE:40017962), complete cds. BC101184 - Homo sapiens cDNA clone IMAGE:40017963, containing frame-shift errors. BC101185 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3, family member E, mRNA (cDNA clone MGC:120037 IMAGE:40017964), complete cds. KJ900580 - Synthetic construct Homo sapiens clone ccsbBroadEn_09974 HTR3E gene, encodes complete protein. AY349353 - Homo sapiens 5-HT3c1 serotonin receptor-like protein mRNA, complete cds; alternatively spliced. EU165354 - Homo sapiens serotonin receptor 3 subunit E splice variant 3 (HTR3E) mRNA, complete cds, alternatively spliced. KJ904151 - Synthetic construct Homo sapiens clone ccsbBroadEn_13545 HTR3E gene, encodes complete protein.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein A5X5Y0 (Reactome details) participates in the following event(s):
R-HSA-975311 HTR3 pentamer:5HT transports Na+,K+, and Ca2+ R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System