Human Gene ANGPTL7 (ENST00000376819.4) from GENCODE V44
Description: Homo sapiens angiopoietin like 7 (ANGPTL7), mRNA. (from RefSeq NM_021146)
Gencode Transcript: ENST00000376819.4
Gencode Gene: ENSG00000171819.5
Transcript (Including UTRs)
Position: hg38 chr1:11,189,355-11,195,981 Size: 6,627 Total Exon Count: 5 Strand: +
Coding Region
Position: hg38 chr1:11,189,580-11,195,023 Size: 5,444 Coding Exon Count: 5
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: ANGL7_HUMAN
DESCRIPTION: RecName: Full=Angiopoietin-related protein 7; AltName: Full=Angiopoietin-like factor; AltName: Full=Angiopoietin-like protein 7; AltName: Full=Cornea-derived transcript 6 protein; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Probable).TISSUE SPECIFICITY: Highly and specifically expressed in the cornea where is confined to the stromal layer.SIMILARITY: Contains 1 fibrinogen C-terminal domain.WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/angptl7/";
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002181 - Fibrinogen_a/b/g_C
IPR014716 - Fibrinogen_a/b/g_C_1
IPR014715 - Fibrinogen_a/b/g_C_2
Pfam Domains: PF00147 - Fibrinogen beta and gamma chains, C-terminal globular domain
ModBase Predicted Comparative 3D Structure on O43827
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding
Biological Process: GO:0006979 response to oxidative stress
Cellular Component: GO:0005576 extracellular region
Descriptions from all associated GenBank mRNAs
LF213890 - JP 2014500723-A/21393: Polycomb-Associated Non-Coding RNAs.MA449467 - JP 2018138019-A/21393: Polycomb-Associated Non-Coding RNAs.AB593027 - Homo sapiens ANGPTL7 mRNA for angiopoietin-related protein 7, complete cds, clone: HP04607-ARiS049I20.AK313716 - Homo sapiens cDNA, FLJ94309, Homo sapiens angiopoietin-like factor (CDT6), mRNA.BC001881 - Homo sapiens angiopoietin-like 7, mRNA (cDNA clone MGC:1422 IMAGE:3544149), complete cds.LF206725 - JP 2014500723-A/14228: Polycomb-Associated Non-Coding RNAs.MA442302 - JP 2018138019-A/14228: Polycomb-Associated Non-Coding RNAs.AB593026 - Homo sapiens ANGPTL7 mRNA for angiopoietin-related protein 7, complete cds, clone: HP04607-ARi15F09.JD311139 - Sequence 292163 from Patent EP1572962.AY358301 - Homo sapiens clone DNA47470 NL4 (UNQ313) mRNA, complete cds.LF357380 - JP 2014500723-A/164883: Polycomb-Associated Non-Coding RNAs.MA592957 - JP 2018138019-A/164883: Polycomb-Associated Non-Coding RNAs.JD360799 - Sequence 341823 from Patent EP1572962.Y16132 - Homo sapiens mRNA for angiopoietin-like factor.CU674908 - Synthetic construct Homo sapiens gateway clone IMAGE:100019043 5' read ANGPTL7 mRNA.DQ895766 - Synthetic construct Homo sapiens clone IMAGE:100010226; FLH187435.01L; RZPDo839H0462D angiopoietin-like 7 (ANGPTL7) gene, encodes complete protein.BT009802 - Homo sapiens angiopoietin-like factor mRNA, complete cds.DQ892555 - Synthetic construct clone IMAGE:100005185; FLH187439.01X; RZPDo839H0472D angiopoietin-like 7 (ANGPTL7) gene, encodes complete protein.KJ892965 - Synthetic construct Homo sapiens clone ccsbBroadEn_02359 ANGPTL7 gene, encodes complete protein.LF357379 - JP 2014500723-A/164882: Polycomb-Associated Non-Coding RNAs.MA592956 - JP 2018138019-A/164882: Polycomb-Associated Non-Coding RNAs.LF357378 - JP 2014500723-A/164881: Polycomb-Associated Non-Coding RNAs.MA592955 - JP 2018138019-A/164881: Polycomb-Associated Non-Coding RNAs.LF357377 - JP 2014500723-A/164880: Polycomb-Associated Non-Coding RNAs.MA592954 - JP 2018138019-A/164880: Polycomb-Associated Non-Coding RNAs.LF357376 - JP 2014500723-A/164879: Polycomb-Associated Non-Coding RNAs.MA592953 - JP 2018138019-A/164879: Polycomb-Associated Non-Coding RNAs.LF357375 - JP 2014500723-A/164878: Polycomb-Associated Non-Coding RNAs.MA592952 - JP 2018138019-A/164878: Polycomb-Associated Non-Coding RNAs.JD511838 - Sequence 492862 from Patent EP1572962.JD441069 - Sequence 422093 from Patent EP1572962.JD051432 - Sequence 32456 from Patent EP1572962.JD060449 - Sequence 41473 from Patent EP1572962.JD332713 - Sequence 313737 from Patent EP1572962.JD499207 - Sequence 480231 from Patent EP1572962.LF357374 - JP 2014500723-A/164877: Polycomb-Associated Non-Coding RNAs.MA592951 - JP 2018138019-A/164877: Polycomb-Associated Non-Coding RNAs.JD487737 - Sequence 468761 from Patent EP1572962.JD227190 - Sequence 208214 from Patent EP1572962.JD255070 - Sequence 236094 from Patent EP1572962.JD299628 - Sequence 280652 from Patent EP1572962.JD359972 - Sequence 340996 from Patent EP1572962.JD564731 - Sequence 545755 from Patent EP1572962.JD499225 - Sequence 480249 from Patent EP1572962.JD440192 - Sequence 421216 from Patent EP1572962.JD480013 - Sequence 461037 from Patent EP1572962.JD468267 - Sequence 449291 from Patent EP1572962.JD308514 - Sequence 289538 from Patent EP1572962.JD073397 - Sequence 54421 from Patent EP1572962.JD157378 - Sequence 138402 from Patent EP1572962.JD392930 - Sequence 373954 from Patent EP1572962.JD271803 - Sequence 252827 from Patent EP1572962.JD165653 - Sequence 146677 from Patent EP1572962.LF357373 - JP 2014500723-A/164876: Polycomb-Associated Non-Coding RNAs.MA592950 - JP 2018138019-A/164876: Polycomb-Associated Non-Coding RNAs.JD301920 - Sequence 282944 from Patent EP1572962.JD073524 - Sequence 54548 from Patent EP1572962.JD155063 - Sequence 136087 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: ANGL7_HUMAN, B2R9B2, CDT6, ENST00000376819.1, ENST00000376819.2, ENST00000376819.3, NM_021146, O43827, Q4ZGK4, uc001ase.1, uc001ase.2, uc001ase.3, uc001ase.4, uc001ase.5, uc001ase.6, UNQ313/PRO356UCSC ID: ENST00000376819.4RefSeq Accession: NM_021146
Protein: O43827
(aka ANGL7_HUMAN)
CCDS: CCDS128.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.