Human Gene SSTR1 (ENST00000267377.3) from GENCODE V44
Description: Homo sapiens somatostatin receptor 1 (SSTR1), mRNA. (from RefSeq NM_001049) RefSeq Summary (NM_001049): Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]. Gencode Transcript: ENST00000267377.3 Gencode Gene: ENSG00000139874.6 Transcript (Including UTRs) Position: hg38 chr14:38,207,904-38,213,067 Size: 5,164 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr14:38,209,390-38,210,565 Size: 1,176 Coding Exon Count: 1
ID:SSR1_HUMAN DESCRIPTION: RecName: Full=Somatostatin receptor type 1; Short=SS-1-R; Short=SS1-R; Short=SS1R; AltName: Full=SRIF-2; FUNCTION: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. SUBUNIT: Interacts with SKB1. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30872
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
