J Int Med Res 2008,
PMID: 18534131
Liu, Y; Huo, X; Pang, X F; Zong, Z H; Meng, X; Liu, G L
Musclin is a muscle-derived secretory peptide that induces insulin resistance in vitro. We studied the effect of musclin (0.5 microg/ml) on insulin-stimulated glucose uptake in rat skeletal muscles and also the effect of rosiglitazone (0.4 microg/ml). Preincubation of muscles with musclin resulted in decreased insulin-stimulated glucose uptake. Musclin also reduced expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha (LXRalpha) mRNAs, although expression of glucose transporter 4 mRNA was unaltered. Rosiglitazone attenuated the effects of musclin on glucose uptake and PPARgamma and LXRalpha mRNA expression. Western blotting demonstrated that activation of protein kinase B (Akt/PKB) in the insulin-signalling cascade was decreased by musclin but corrected by rosiglitazone. These findings suggest that musclin-induced impairment of insulin-stimulated glucose uptake in skeletal muscle is related to Akt/PKB inhibition and might be modulated by PPARgamma/LXRalpha.
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Text Mining Data
Akt/protein kinase B ⊣ Musclin: "
Musclin inhibits insulin activation of
Akt/protein kinase B in rat skeletal muscle
"
Akt/protein ⊣ Musclin: "
Musclin inhibits insulin activation of Akt/protein kinase B in rat skeletal muscle
"
insulin ⊣ Musclin: "
Musclin inhibits insulin activation of Akt/protein kinase B in rat skeletal muscle
"
insulin → Akt/protein kinase B: "
Musclin inhibits insulin activation of Akt/protein kinase B in rat skeletal muscle
"
insulin → Akt/protein: "
Musclin inhibits insulin activation of Akt/protein kinase B in rat skeletal muscle
"
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