Gene interactions and pathways from curated databases and text-mining
Leukemia & lymphoma 2011, PMID: 21299459

Regulation of mammalian target of rapamycin and mitogen activated protein kinase pathways by BCR-ABL.

Redig, Amanda J; Vakana, Eliza; Platanias, Leonidas C

A large body of evidence has established that BCR-ABL regulates engagement and activation of mammalian target of rapamycin (mTOR) and mitogen activated protein kinase (MAPK) signaling cascades. mTOR-mediated signals, as well as signals transduced by ERK, JNK, and p38 MAPK, are important components of the aberrant signaling induced by BCR-ABL. Such deregulation of mTOR or MAPK pathways contributes to BCR-ABL leukemogenesis, and their targeting with selective inhibitors provides an approach to enhance antileukemic responses and/or overcome leukemic cell resistance in chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). This review explores recent advances in our understanding of mTOR and MAPK signaling in BCR-ABL-expressing leukemias and discusses the potential therapeutic targeting of these pathways in CML and Ph+ ALL.

Diseases/Pathways annotated by Medline MESH: Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Document information provided by NCBI PubMed

Text Mining Data

mitogen activated protein kinase → BCR-ABL: " A large body of evidence has established that BCR-ABL regulates engagement and activation of mammalian target of rapamycin (mTOR) and mitogen activated protein kinase ( MAPK ) signaling cascades "

mitogen activated protein kinase → BCR-ABL: " A large body of evidence has established that BCR-ABL regulates engagement and activation of mammalian target of rapamycin (mTOR) and mitogen activated protein kinase ( MAPK ) signaling cascades "

mammalian target of rapamycin (mTOR) → BCR-ABL: " A large body of evidence has established that BCR-ABL regulates engagement and activation of mammalian target of rapamycin (mTOR) and mitogen activated protein kinase ( MAPK ) signaling cascades "

mammalian target of rapamycin (mTOR) → BCR-ABL: " A large body of evidence has established that BCR-ABL regulates engagement and activation of mammalian target of rapamycin (mTOR) and mitogen activated protein kinase ( MAPK ) signaling cascades "

Manually curated Databases

No curated data.