We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to MTOR

MTOR — RELA

Text-mined interactions from Literome

Minhajuddin et al., J Immunol 2005 : Inhibition of mTOR by this approach promoted whereas over-expression of mTOR inhibited thrombin induced transcriptional activity of NF-kappaB , an essential regulator of ICAM-1 transcription ... Consistent with these data, we observed a more efficient and stable nuclear localization of RelA/p65 and, subsequently, the DNA binding activity of NF-kappaB by thrombin following mTOR inhibition
Djavaheri-Mergny et al., J Biol Chem 2006 : This repression is associated with an NF-kappaB dependent activation of the autophagy inhibitor mTOR
Brown et al., Ann Clin Lab Sci 2006 (Neoplasms, Squamous Cell...) : Because the mammalian target of the rapamycin (mTOR) pathway contributes to the activation of NF-kappaB through immunophilin/mTOR signaling , we investigated : ( a ) the immunohistochemical expression and state of activation and potential clinical significance of components of the mTOR signal transduction pathway in SCCT patients ( morphoproteomics ) ; and ( b ) the inhibitory effects of rapamycin on the growth and state of activation of mTOR in 2 HNSCC cell lines ( pharmacoproteomics )
Ghosh et al., Cancer Cell 2006 (MAP Kinase Signaling System) : Furthermore, in TSC2 ( -/- ) MEFs, the rapamycin mediated inhibition of deregulated mTOR activity restored NF-kappaB activation and survival
Dan et al., Genes Dev 2008 (Prostatic Neoplasms) : Akt dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK ... We show here that mTOR downstream from Akt controls NF-kappaB activity in PTEN-null/inactive prostate cancer cells via interaction with and stimulation of IKK
Park et al., Cancer Res 2009 (Brain Neoplasms...) : However, unlike other signals that regulate mTOR activity without affecting its level, RIP1 negatively regulates mTOR transcription via a NF-kappaB dependent mechanism
Ahmed et al., Molecular cancer 2010 (Breast Neoplasms) : Moreover, overexpression of mTOR inhibits OPN induced NF-kappaB and AP-1-DNA binding and transcriptional activity