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AHR — IL12B

Text-mined interactions from Literome

Kuribayashi et al., Clin Exp Allergy 2002 (Asthma...) : We investigated whether IL-12 administered after antigen challenge could diminish airway hyper-reactivity (AHR) and eosinophilia in mice actively sensitized to ovalbumin ... Mice were analysed for effects of IL-12 on AHR , inflammatory cell infiltration and cytokine levels in lung tissue as well as serum immunoglobulin ( Ig ) E levels ... These data indicate that IL-12 can attenuate established antigen induced AHR and inflammation
Onari et al., Clin Exp Allergy 2009 (Asthma...) : The results suggest that endogenous IL-12p40 is essential for inhibition of AHR and peribronchial fibrosis, but not eosinophilic inflammation, in a murine asthma model with prolonged antigen exposures