Rothbart et al., Cancer Res 2010
:
Whereas AMPK activation resulted in marked inhibition of mTORC1 , other targets of AMPK were phosphorylated that were not mTORC1 dependent
Chao et al., J Agric Food Chem 2011
(Glioblastoma) :
Activation of AMPK induces a-mangostin mediated phosphorylation of raptor, which subsequently associates with 14-3-3? and results in the loss of mTORC1 activity
Jung et al., J Toxicol Sci 2012
:
In conclusion, OA increases the proliferation and decreases the starvation induced apoptosis of SK-Hep1 cells via mTORC1 activation mediated by negative regulation of AMPK