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AKT3 — RHOA
Text-mined interactions from Literome
Viswambharan et al., Circ Res 2004
:
In conclusion, rHDL inhibits thrombin induced human endothelial TF expression through inhibition of
RhoA and
activation of PI3K but not
Akt/eNOS
Reuveny et al., FEBS Lett 2004
:
Here, we show that inhibition of
RhoA prevents the phosphorylation of
Akt , but does not affect the phosphorylation of ERK
Ueda et al., Exp Cell Res 2004
:
Galphaq/11 signaling induces apoptosis through two pathways involving reduction of
Akt phosphorylation and
activation of
RhoA in HeLa cells
Gakidis et al., J Cell Biol 2004
:
beta2 induced activation of Cdc42, Rac1, and
RhoA is defective in Vav1/3ko neutrophils, and phosphorylation of Pyk2, paxillin, and
Akt is also significantly
reduced
Liao et al., J Investig Med 2004
(Cardiomegaly...) :
Furthermore, inhibition of
RhoA by statins
leads to the activation of protein kinase
B/Akt and up-regulation of endothelial nitric oxide synthase in the endothelium and the heart
Mital et al., Semin Vasc Med 2004
(Cardiomegaly) :
Furthermore, inhibition of
RhoA by statins
leads to the activation of protein kinase
B/Akt and upregulation of Type 3 nitric oxide synthase in the endothelium and the heart
Khwaja et al., Kidney Int 2006
:
GGTI 298 increased cytosolic expression of RhoA, prevented
RhoA activation, and
inhibited the activation of Erk1/2 and the survival protein
Akt
Guilluy et al., J Biol Chem 2007
(Anoxia...) :
In contrast, inhibition of 5-HT mediated
RhoA degradation by MG132
prevented 5-HT induced
Akt activation
Charette et al., Oncogene 2007
:
Increased migration in E7-expressing HFKs correlated with an
Akt regulated downregulation of
RhoA activity through p27 binding under conditions where a p27 nuclear import signal is given ( that is, DNA damage )
Del Re et al., J Biol Chem 2008
:
Inhibition of
RhoA mediated
Akt activation at any of these steps, including inhibition of FAK, prevents RhoA from protecting cardiomyocytes against apoptotic insult
Nandy et al., J Cell Mol Med 2010
(Diabetes Mellitus, Type 2) :
Paradoxically, inhibition of GSK-3beta phosphorylation also augmented monocyte migration in THP-1, ND and diabetic monocytes through phosphorylation of
AKT and
activation of
Rho-A that was independent of GSK
Liu et al., Cell Signal 2013
(Stomach Neoplasms) :
PI3K/Akt dependent phosphorylation of GSK3ß and activation of
RhoA regulate Wnt5a induced gastric cancer cell migration
Wang et al., Ann Neurol 2013
(Brain Ischemia...) :
Furthermore, rADAMTS13 downregulated tPA induced phosphorylation of
Akt and
activation of
RhoA
Zhang et al., Circ Res 2013
(Hyperplasia...) :
Inhibition or deletion of EP3a/ß, a Gai protein coupled receptor, activated the cAMP/protein kinase A pathway and decreased activation of
RhoA in VSMCs. PGE2 could
stimulate phosphatidylinositol
3-kinase/Akt/glycogen synthase kinase3ß signaling in VSMCs through Gß? subunits on EP3a/ß activation