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APC — BCL2
Text-mined interactions from Literome
Griffin et al., Crit Care Med 2004
(Brain Ischemia...) :
In these cells,
APC blunts hypoxia induced increases in p53 messenger RNA and protein, reduces pro-apoptotic Bax, and
increases anti-apoptotic
Bcl-2 , thereby inhibiting mitochondrial dependent apoptosis
Brocardo et al., J Biol Chem 2008
(Colonic Neoplasms) :
APC formed a complex with Bcl-2 in mitochondrial fractions, and this may
contribute to the APC dependent regulation of
Bcl-2 ... We propose that a subset of cancer mutations induce APC mitochondrial localization and that
APC regulation of
Bcl-2 at mitochondria may contribute to tumor cell survival