Gene interactions and pathways from curated databases and text-mining

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APC — BCL2

Text-mined interactions from Literome

Griffin et al., Crit Care Med 2004 (Brain Ischemia...) : In these cells, APC blunts hypoxia induced increases in p53 messenger RNA and protein, reduces pro-apoptotic Bax, and increases anti-apoptotic Bcl-2 , thereby inhibiting mitochondrial dependent apoptosis
Brocardo et al., J Biol Chem 2008 (Colonic Neoplasms) : APC formed a complex with Bcl-2 in mitochondrial fractions, and this may contribute to the APC dependent regulation of Bcl-2 ... We propose that a subset of cancer mutations induce APC mitochondrial localization and that APC regulation of Bcl-2 at mitochondria may contribute to tumor cell survival