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ARAF — HSP90AA1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Grbovic et al., Proc Natl Acad Sci U S A 2006
(Melanoma) :
We show that Raf-1 and
A-Raf require
Hsp90 for stability, whereas B-Raf does not
Haarberg et al., Mol Cancer Ther 2013
(Melanoma) :
In vitro,
HSP90 inhibition
led to the degradation of
ARAF , CRAF, Wee1, Chk1, and cdc2 and was associated with decreased mitogen activated protein kinase ( MAPK ), AKT, mTOR, and c-jun NH2 kinase ( JNK ) signaling