Gene interactions and pathways from curated databases and text-mining

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CASP16 — IRS1

Text-mined interactions from Literome

Kang et al., J Biol Chem 2007 (Anoxia) : Our findings indicate that transient hypoxia ( 1 % oxygen ) leads to caspase mediated cleavage of IRS-1 without inducing cell death
Kim et al., Apoptosis 2009 (Neuroblastoma) : In the presence of high glucose, IRS-1 underwent caspase mediated degradation, followed by focal adhesion kinase ( FAK ) and Akt degradation and apoptosis