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CAV3 — VEGFA

Text-mined interactions from Literome

Feng et al., Biochem Biophys Res Commun 1999 : VEGF induces nuclear translocation of Flk-1/KDR, endothelial nitric oxide synthase, and caveolin-1 in vascular endothelial cells ... Because eNOS activity is regulated by its interaction with the caveolar structural protein caveolin-1, we analyzed VEGF effects on structural interactions between eNOS, caveolin-1 and the VEGF receptor Flk-1/KDR
Liu et al., J Biol Chem 1999 : Angiogenesis inhibitors block vascular endothelial growth factor induced down-regulation of caveolin-1 ... VEGF induced down-regulation of caveolin-1 expression also resulted in the morphological loss of cell surface caveolae organelles as seen by transmission electron microscopy ... A variety of well characterized angiogenesis inhibitors ( including angiostatin, fumagillin, 2-methoxy estradiol, transforming growth factor-beta, and thalidomide ) effectively blocked VEGF induced down-regulation of caveolin-1 as seen by immunoblotting and immunofluorescence microscopy ... PD98059, a specific inhibitor of mitogen activated protein kinase and a known angiogenesis inhibitor, also blocked the observed VEGF induced down-regulation of caveolin-1
Brouet et al., J Biol Chem 2001 : Accordingly, we showed that early VEGF stimulation first leads to the Ca ( 2+ ) /calmodulin disruption of the caveolin-eNOS complex and promotes the association between eNOS and hsp90
Labrecque et al., J Biol Chem 2004 : In this study, we provide evidence that the VEGF dependent tyrosine phosphorylation of caveolin-1 induces interaction of the protein with the membrane-type 1 matrix metalloproteinase ( MT1-MMP )
Podar et al., Cancer Res 2004 (Multiple Myeloma) : In the present study, we demonstrate that vascular endothelial growth factor ( VEGF ) triggers Src dependent phosphorylation of caveolin-1 , which is required for p130 ( Cas ) phosphorylation and multiple myeloma cell migration ... Bortezomib also decreased VEGF secretion in the bone marrow microenvironment and inhibited VEGF triggered tyrosine phosphorylation of caveolin-1 , migration, and survival in human umbilical vascular endothelial cells
Hawkins et al., J Neurosci 2010 : Pharmacological activation of Src kinase activity mimicked the effects of VEGF on P-glycoprotein activity and Tyr-14 phosphorylation of caveolin-1
Wu et al., American journal of physiology. Renal physiology 2013 : VEGF stimulation led to a markedly increased VEGFR2/caveolin-1 but failed to increase VEGFR1/caveolin-1 association