Gene interactions and pathways from curated databases and text-mining

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CCL2 — PDGFB

Text-mined interactions from Literome

Ping et al., J Biol Chem 1999 : These results show that the mechanisms of PDGF-BB and TNF activation of MCP-1 are distinct, although they both require the proximal regulatory region Sp1 binding site
Masamune et al., Biochem Pharmacol 2005 : Ellagic acid inhibited platelet derived growth factor (PDGF)-BB induced proliferation and migration, interleukin (IL)-1beta- and tumor necrosis factor (TNF)-alpha induced monocyte chemoattractant protein-1 production, and expression of alpha-smooth muscle actin and collagen genes
Liu et al., J Mol Cell Cardiol 2006 : PDGF-BB enhances monocyte chemoattractant protein-1 mRNA stability in smooth muscle cells by downregulating ribonuclease activity
Au et al., Am J Pathol 2009 : PDGF-BB stimulated the expression of both chemokine (C-C motif) ligand 2 ( CCL2 ) and CCL7 in 10T1/2 cells and led to the increased accumulation of macrophages in vivo
van Steensel et al., Invest Ophthalmol Vis Sci 2010 (Graves Ophthalmopathy) : IL-6, IL-8, CCL2 , CCL5, and CCL7 production by orbital fibroblasts was increased by PDGF-BB stimulation, whereas IL-16, IL-1beta, and TNF-alpha production was not affected
Sumiyoshi et al., Br J Nutr 2010 (Body Weight...) : Plasma levels of monocyte chemoattractant protein (MCP)-1 were elevated, and the level of hepatic platelet derived growth factor (PDGF)-B protein was increased in mice fed the HC diet compared with those fed the control diet
Bethel-Brown et al., Journal of neuroinflammation 2012 (HIV Infections) : Platelet derived growth factor (PDGF)-BB mediated induction of monocyte chemoattractant protein 1 in human astrocytes : implications for HIV associated neuroinflammation ... We have previously demonstrated that HIV-1/HIV-1 Tat upregulate platelet derived growth factor (PDGF)-BB, a known cerebrovascular permeant ; subsequently, the present study was aimed at exploring the regulation of MCP-1 by PDGF-BB in astrocytes with implications in HAND