Gene interactions and pathways from curated databases and text-mining

◀ Back to LEP

CCNC — LEP

Text-mined interactions from Literome

Elmquist et al., Physiol Behav 2001 (Body Weight) : We found that leptin activates neurons in the retrochiasmatic area ( RCA ) and lateral arcuate nucleus (Arc) that innervate the sympathetic preganglionic neurons in the thoracic spinal cord and also contain cocaine- and amphetamine regulated transcript ( CART )
Proulx et al., Endocrinology 2002 (Weight Gain) : In the arcuate nucleus (ARC) , acute leptin increased SOCS-3 and POMC mRNA levels, but decreased NPY mRNA levels in the rostral part of ARC
Steinberg et al., Endocrinology 2006 (Obesity) : Both leptin and CNTF reduced AMPK activity and acetyl-coenzyme A carboxylase phosphorylation in the ARC and PVN of control fed mice
Ambati et al., Biofactors 2007 (Body Weight) : Leptin and CNTF increased ARC-ME mRNA levels of signal transducer and activator of transcription 3 ( STAT3 ) by 64.5 and 124.7 % ( p < 0.01 ), suppressor of cytokine signaling 3 ( SOCS3 ) by 258.9 and 1063.9 % ( p < 0.01 ), cocaine and amphetamine regulated transcript ( CART ) by 102.7 and 123.1 % ( p < 0.01 ), and proopiomelanocortin ( POMC2 ) by 374.1 and 264.9 % ( p < 0.01 ), respectively
Kirk et al., PloS one 2009 (Hyperphagia...) : At postnatal Day 30, before the onset of hyperphagia in these animals, serum leptin is normal, but leptin induced appetite suppression and phosphorylation of STAT3 in the arcuate nucleus (ARC) are attenuated ; the level of AgRP-immunoreactivity in the hypothalamic paraventricular nucleus ( PVH ), which derives from neurones in the ARC and is developmentally dependent on leptin, is also diminished
Qi et al., Endocrinology 2010 : It is widely accepted that leptin acts on first-order neurons in the arcuate nucleus (ARC) with information then relayed to other hypothalamic centers ... We used a model of hypothalamo-pituitary disconnection ( HPD ) to determine whether leptin action on appetite regulating systems requires the ARC
Quennell et al., Endocrinology 2011 (Body Weight...) : In mice with normalized levels of estradiol, leptin deficiency markedly reduced kisspeptin gene expression, particularly in the arcuate nucleus (ARC) , and kisspeptin immunoreactive cell numbers in the rostral periventricular region of the third ventricle ( RP3V )
Riediger et al., Proc Nutr Soc 2012 (Obesity...) : PYY and leptin also reverse or prevent fasting induced activation of the ARC
Elias et al., Neuron 1998 (Body Weight) : We found that leptin activates neurons in the retrochiasmatic area ( RCA ) and lateral arcuate nucleus (Arc) that innervate the thoracic spinal cord and also contain cocaine- and amphetamine regulated transcript ( CART )