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CCR5 — IFNG
Text-mined interactions from Literome
Majka et al., J Clin Invest 1999
:
We found that human CD34 ( + ) cells and CD34 ( + ) KIT ( + ) cells, which are enriched in myeloid progenitor cells, expressed and secreted the
CCR5 ligands RANTES, MIP-1alpha, and MIP-1beta and that
IFN-gamma stimulated expression of these chemokines
Biasin et al., J Infect Dis 2000
:
However, interleukin (IL)-6, IL-10, IL-12,
interferon (IFN)-gamma , and tumor necrosis factor (TNF)-alpha and -beta mRNA were elevated in PBMC and cervical mucosa biopsy specimens of ESN and HIV infected women ;
CCR5 and CXCR4 mRNA were
augmented in cervical mucosa biopsy specimens, but not in PBMC, of ESN and HIV infected women ; HIV-specific IFN-gamma secreting cells were detected in vaginal washes of ESN and HIV infected women ; and phenotypic alterations were present in PBMC of ESN women
Langrish et al., Clin Exp Immunol 2002
:
Cord DCs were also unable to produce IL-12p70, failed to down-regulate expression of the chemokine receptor
CCR5 and
induced lower levels of
IFN-gamma production from allogeneic naive CD4+ T cells than their adult counterparts
Losana et al., J Leukoc Biol 2002
(HIV Infections) :
IFN-gamma and IL-12 differentially
regulate CC-chemokine secretion and
CCR5 expression in human T lymphocytes ... Neutralization of IFN-gamma increased CCR5 expression and decreased CC-chemokine secretion by CD4 ( + ) clones from healthy and IL-12Rbeta1 ( -/- ) individuals, suggesting an
IFN-gamma dependent control of
CCR5 expression
Vicenzi et al., J Leukoc Biol 2002
:
Interferon-gamma (IFN-gamma) down-regulated
CCR5 in Th1 cells and inhibited, whereas interleukin-4 (IL-4) up-regulated CXCR4 and enhanced the spreading of R5 and R5X4 viruses in polarized CB lines
Croitoru-Lamoury et al., Glia 2003
:
Expression of chemokines and their receptors in human and simian astrocytes : evidence for a central
role of TNF alpha and
IFN gamma in CXCR4 and
CCR5 modulation
Creery et al., Clin Exp Immunol 2004
(HIV Infections) :
To determine if IFN-gamma regulates HIV replication by altering CXCR-4/CCR-5 expression and hence virus entry into monocytic cells, we investigated the
effects of
IFN-gamma on CXCR-4 and
CCR-5 expression and its biological implications with respect to HIV entry, replication and chemotaxis towards the CXCR-4 and CCR-5 ligands SDF-1 and MIP-1alpha, respectively ... These results suggest that although
IFN-gamma induced down-regulation of CXCR-4 and
CCR-5 expression is associated with an inhibition of SDF-1-/MIP-1alpha mediated chemotaxis, IFN-gamma induced inhibition of HIV replication may be mediated at levels subsequent to the virus entry
Bosco et al., Adv Exp Med Biol 2003
:
In contrast, we found that
IFNgamma increased
CCR5 basal expression, whereas PA down-regulated both constitutive and IFNgamma induced CCR5 mRNA and protein levels
Ma et al., J Clin Invest 2005
(Emphysema...) :
They also demonstrate that
CCR5 is
required for optimal
IFN-gamma stimulation of its own ligands, other chemokines, MMPs, caspases, and cell death regulators and the inhibition of antiproteases
Liu et al., J Clin Invest 2008
(Melanoma, Experimental) :
NK cell recruitment was mediated by
CCR5 via chemokines secreted by pDCs, and optimal
IFN-gamma production by NK cells was
mediated by OX40L expressed by pDCs
Zella et al., Blood 1998
:
Interferon-gamma increases expression of chemokine receptors CCR1,
CCR3 , and CCR5, but not CXCR4 in monocytoid U937 cells ... We demonstrate here that
interferon-gamma (IFN-gamma) increases the expression of chemokine receptors CCR1, CCR3, and
CCR5 in monocytoid U937 cells as detected by cell surface molecule labeling and mRNA expression, as well as by intracellular calcium mobilization and cell migration in response to specific ligands
Hariharan et al., Blood 1999
:
Interferon-gamma upregulates
CCR5 expression in cord and adult blood mononuclear phagocytes ... Monocytes treated with IFN-gamma showed increased chemotaxis to the CCR5 ligands macrophage inflammatory protein-1alpha ( MIP-1alpha ) and MIP-1beta, confirming the functional relevance of
IFN-gamma induced
CCR5 expression