Gene interactions and pathways from curated databases and text-mining

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CCR5 — IFNG

Text-mined interactions from Literome

Majka et al., J Clin Invest 1999 : We found that human CD34 ( + ) cells and CD34 ( + ) KIT ( + ) cells, which are enriched in myeloid progenitor cells, expressed and secreted the CCR5 ligands RANTES, MIP-1alpha, and MIP-1beta and that IFN-gamma stimulated expression of these chemokines
Biasin et al., J Infect Dis 2000 : However, interleukin (IL)-6, IL-10, IL-12, interferon (IFN)-gamma , and tumor necrosis factor (TNF)-alpha and -beta mRNA were elevated in PBMC and cervical mucosa biopsy specimens of ESN and HIV infected women ; CCR5 and CXCR4 mRNA were augmented in cervical mucosa biopsy specimens, but not in PBMC, of ESN and HIV infected women ; HIV-specific IFN-gamma secreting cells were detected in vaginal washes of ESN and HIV infected women ; and phenotypic alterations were present in PBMC of ESN women
Langrish et al., Clin Exp Immunol 2002 : Cord DCs were also unable to produce IL-12p70, failed to down-regulate expression of the chemokine receptor CCR5 and induced lower levels of IFN-gamma production from allogeneic naive CD4+ T cells than their adult counterparts
Losana et al., J Leukoc Biol 2002 (HIV Infections) : IFN-gamma and IL-12 differentially regulate CC-chemokine secretion and CCR5 expression in human T lymphocytes ... Neutralization of IFN-gamma increased CCR5 expression and decreased CC-chemokine secretion by CD4 ( + ) clones from healthy and IL-12Rbeta1 ( -/- ) individuals, suggesting an IFN-gamma dependent control of CCR5 expression
Vicenzi et al., J Leukoc Biol 2002 : Interferon-gamma (IFN-gamma) down-regulated CCR5 in Th1 cells and inhibited, whereas interleukin-4 (IL-4) up-regulated CXCR4 and enhanced the spreading of R5 and R5X4 viruses in polarized CB lines
Croitoru-Lamoury et al., Glia 2003 : Expression of chemokines and their receptors in human and simian astrocytes : evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation
Creery et al., Clin Exp Immunol 2004 (HIV Infections) : To determine if IFN-gamma regulates HIV replication by altering CXCR-4/CCR-5 expression and hence virus entry into monocytic cells, we investigated the effects of IFN-gamma on CXCR-4 and CCR-5 expression and its biological implications with respect to HIV entry, replication and chemotaxis towards the CXCR-4 and CCR-5 ligands SDF-1 and MIP-1alpha, respectively ... These results suggest that although IFN-gamma induced down-regulation of CXCR-4 and CCR-5 expression is associated with an inhibition of SDF-1-/MIP-1alpha mediated chemotaxis, IFN-gamma induced inhibition of HIV replication may be mediated at levels subsequent to the virus entry
Bosco et al., Adv Exp Med Biol 2003 : In contrast, we found that IFNgamma increased CCR5 basal expression, whereas PA down-regulated both constitutive and IFNgamma induced CCR5 mRNA and protein levels
Ma et al., J Clin Invest 2005 (Emphysema...) : They also demonstrate that CCR5 is required for optimal IFN-gamma stimulation of its own ligands, other chemokines, MMPs, caspases, and cell death regulators and the inhibition of antiproteases
Liu et al., J Clin Invest 2008 (Melanoma, Experimental) : NK cell recruitment was mediated by CCR5 via chemokines secreted by pDCs, and optimal IFN-gamma production by NK cells was mediated by OX40L expressed by pDCs
Zella et al., Blood 1998 : Interferon-gamma increases expression of chemokine receptors CCR1, CCR3 , and CCR5, but not CXCR4 in monocytoid U937 cells ... We demonstrate here that interferon-gamma (IFN-gamma) increases the expression of chemokine receptors CCR1, CCR3, and CCR5 in monocytoid U937 cells as detected by cell surface molecule labeling and mRNA expression, as well as by intracellular calcium mobilization and cell migration in response to specific ligands
Hariharan et al., Blood 1999 : Interferon-gamma upregulates CCR5 expression in cord and adult blood mononuclear phagocytes ... Monocytes treated with IFN-gamma showed increased chemotaxis to the CCR5 ligands macrophage inflammatory protein-1alpha ( MIP-1alpha ) and MIP-1beta, confirming the functional relevance of IFN-gamma induced CCR5 expression