◀ Back to EPHB2

CD24 — EPHB2

Text-mined interactions from Literome

Su et al., Molecular cancer 2012 (Colorectal Neoplasms...) : Lyn is involved in CD24 induced ERK1/2 activation in colorectal cancer ... Since Src family kinases are frequently deregulated in CRC and closely related to the MAPK signaling pathway, we investigated the impact of Lyn, an important member of SFKs, on CD24 induced ERK1/2 activation in CRC ... However, inhibition of Lyn activity attenuated CD24 induced ERK1/2 activation, and depletion of CD24 disrupted Lyn-ERK1/2 interaction ... Our results suggest that Lyn is involved in CD24 induced ERK1/2 activation in CRC
Lee et al., Cell Signal 2012 : Our results suggest that down-regulation of Raf/MEK/ERK signaling via Src/FAK may be dependent on integrin ß1 function and that this mechanism is largely responsible for the CD24 ablation induced decreases in cell proliferation and epithelial to mesenchymal transition