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CD40LG — PTBP1

Text-mined interactions from Literome

Jonuleit et al., J Exp Med 2000 : Only stimulation of T cells with mature DCs resulted in an upregulation of CD154 , CD69, and CD70, whereas T cells activated with immature DCs showed an early upregulation of the negative regulator cytotoxic T lymphocyte associated molecule 4 ( CTLA-4 )
Vissers et al., J Leukoc Biol 2001 : Activation of DCs by CD40 ligand further up-regulated the expression of ELC ( 25-fold )
Vidalain et al., J Immunol 2001 : Unexpectedly, CD40L activated DCs still developed cytotoxicity toward tumoral cells
Mehlhop et al., J Immunol Methods 2002 (Simian Acquired Immunodeficiency Syndrome) : In general, macaque DCs exhibited weaker responses to LPS and Poly I:C than human DCs, and soluble CD40L stimulation induced variable expression of CD25
Gilliet et al., Hum Immunol 2002 : Here we review the recent evidence that cluster designation (CD)40-ligand activated plasmacytoid derived DCs ( DC2 ) have the ability to induce primary Tr-cell differentiation
Kuwana et al., Hum Immunol 2002 : Human DC subsets with the property of suppressing an antigen-specific T-cell response include plasmacytoid DCs , which are either in an immature state or in a mature state induced by CD40 ligand stimulation, and monocyte derived DCs, which are either in an immature state or have had their state modulated by treatment with IL-10 or CD8 ( + ) CD28 ( - ) T cells
Yu et al., J Immunol 2003 (HIV Infections) : TNF-alpha and RANKL cooperated with CD40L via differing mechanisms, i.e., TNF-alpha enhanced IL-12 production, whereas RANKL enhanced survival of CD40L stimulated DCs ... In HIV-1 infection, DCs may only require CD40L to maximally expand CTL
Costa et al., Infect Immun 2004 (Leishmaniasis) : In addition, a decrease in the maturation of DCs induced by CD40L was observed in the presence of SGH
Zou et al., Cancer Immunol Immunother 2004 (Myelodysplastic Syndromes) : Exogenous LIGHT- and CD40L stimulated mature DCs ( mDCs ) also displayed increased antigen presentation to autologous T lymphocytes ( tetanus toxin ) or allogeneic T lymphocytes in mixed lymphocyte reactions
Yu et al., J Immunol 2004 : Finally, the p38 MAPK pathway was most important in mediating CD40L stimulated DCs to induce strong allogeneic responses as well as expanding virus-specific memory CD8 ( + ) T cell responses
Nourizadeh et al., Iran J Allergy Asthma Immunol 2007 (Agammaglobulinemia...) : Interleukin 18 (IL-18) production by CD40L activated mature DCs was measured after 24 hours of culture in vitro.IL-18 production by DCs generated in the presence of CVID and XLA patients ' sera were 6.75+/-2.59 and 7.08+/-1.75 ng/ml, respectively, which were significantly higher than normal serum conditioned DCs ( 3.55+/-0.68 ) ng/ml
Gu et al., Cell Mol Immunol 2008 (Neoplasms) : Differential expression patterns of PD-L1 and PD-L2 were found when DCs were triggered by CD40 ligand and TNF-alpha
Zhang et al., Biochem Biophys Res Commun 2009 (Neoplasms) : CD40L , the ligand for CD40 on dendritic cells (DCs), plays an important role in maturation and activation of DCs leading to induction of immune responses
Mnasria et al., Transplant Proc 2009 (Acute Disease) : In this study, we observed that stimulation of human monocyte derived DCs with lipopolysa ccharide or CD40L strongly induced the expression of CD25
Wong et al., J Immunol 2009 : IL-12p70 production was produced predominantly by CD8alpha ( + ) DCs and plasmacytoid DCs , and mediated by CD8 T cell derived cytokines IFN-gamma, GM-CSF, TNF-alpha, and surface CD40L
Conzelmann et al., Biochem Pharmacol 2010 : CD40L induces activation of antigen presenting cells (APCs) such as DCs , monocytes, B-cells and endothelial cells
Matus-Nicodemos et al., J Immunol 2011 : Together this work suggests that differentially modified PTB regulates CD40L expression at multiple steps by 1 ) retaining CD40L mRNA in the nucleus, 2 ) directly regulating mRNA stability at late times of activation, and 3 ) forming a ribonuclear complex that preferentially associates with translating ribosomes thus leading to an enhanced level of CD40L protein
Nolte et al., Eur J Immunol 2013 : With ( out ) a little help from my friends : an IL-12/CD40L mediated feed-forward loop between CD8+ T cells and DCs