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CD44 — IL10

Text-mined interactions from Literome

Ashkar et al., Science 2000 (Granuloma...) : A phosphorylation dependent interaction between the amino-terminal portion of Eta-1 and its integrin receptor stimulated IL-12 expression, whereas a phosphorylation independent interaction with CD44 inhibited IL-10 expression
Gee et al., J Immunol 2002 : However, neither p38 nor p42/44 MAPKs were involved in IL-10 induced CD44 expression in monocytes
Bollyky et al., J Immunol 2009 : CD44 costimulation increased production of IL-10 in a partially IL-2 dependent manner and also promoted cell surface TGF-beta expression
Osada et al., J Invest Dermatol 1995 : We examined the modulatory effects of tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 on the CD44 expression in LC ... We found 1 ) that TNF-alpha significantly up-regulated the expression of CD44 in a concentration dependent manner, 2 ) that IL-10 down-regulated the expression of CD44 in a concentration dependent manner, 3 ) that the effect of TNF-alpha or IL-10 was readily detectable as early as 24 h after the initiation of culture, and 4 ) that the simultaneous addition of TNF-alpha and IL-10 mutually neutralized the effect of each other ... These data suggest that in the epidermal microenvironment the expression of CD44 in LC may be reciprocally regulated by TNF-alpha and IL-10 , both of which are known to be produced by surrounding keratinocytes
Levesque et al., J Immunol 1997 (Inflammation) : Alone, IL-10 induced HA binding to PBMC monocyte CD44 , while in contrast, IL-10 inhibited IL-1 induced monocyte CD44 binding to HA