Gene interactions and pathways from curated databases and text-mining

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CD55 — MAPK1

Text-mined interactions from Literome

Takeuchi et al., J Lab Clin Med 2001 : The EGF induced DAF expression was inhibited by mitogen activated protein ( MAP ) kinase kinase inhibitor PD 98059 but not by phosphatidylinositol-3 kinase inhibitor, phospholipase Cgamma inhibitor, or protein kinase C inhibitor
Mason et al., Am J Physiol Cell Physiol 2002 : Investigation of mitogen activated kinase ( MAPK ) pathways also revealed differences, with bFGF induced DAF dependent on p44/42 and p38 MAPK and VEGF requiring activation of p38 MAPK alone
Lidington et al., Am J Physiol Cell Physiol 2005 (MAP Kinase Signaling System) : ERK1/2, p38, and JNK MAPK were also involved in thrombin induced DAF upregulation, with evidence of interdependence between ERK1/2 and JNK
Nakdimon et al., PLoS Genet 2012 (Neoplasms) : The insulin receptor DAF-2 stimulates , while DAF-18 PTEN inhibits, RAS/MAPK signaling in the vulval precursor cells ... Genetic and biochemical analyses indicate that DAF-18 negatively regulates vulval induction by inhibiting MAPK activation
Komura et al., Biogerontology 2013 : As skn-1 induces phase 2 detoxification enzymes, our findings suggest that cell wall components of bifidobacteria increase the average lifespan of C. elegans via activation of skn-1, regulated by the p38 MAPK pathway, but not by general activation of the host defense system via DAF-16