Gene interactions and pathways from curated databases and text-mining

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CTLA4 — IL5

Text-mined interactions from Literome

Blazevic et al., J Clin Immunol 2001 : Inhibition studies using the B7-binding fusion protein CTLA4Ig and antibodies against CD80 and CD86 demonstrate that CTLA4Ig and anti-CD86 inhibited influenza-specific T cell proliferation, interleukin (IL)-2 and interferon (IFN)-gamma production, and generation of influenza-specific CD8+ CTL
Lordan et al., J Allergy Clin Immunol 2001 (Asthma) : Consistent with increased transcription, allergen stimulated IL-5 protein release into explant supernatants, but this was not blocked by CTLA-4Ig ... In contrast, allergen enhanced production of IL-5 and IL-13 by PBMC cultures from the same subjects, and this was inhibited effectively by CTLA-4Ig
Steel et al., J Immunol 2003 (Filariasis...) : Finally, in vitro blocking of CTLA-4 expression in PBMC from filaria infected individuals induced a mean increase of 44 % in IL-5 production to Mf Ag, whereas there was a concurrent mean decrease of 42 % in IFN-gamma production, suggesting that CTLA-4 also acts to alter the Th1/Th2 balance in filaria infected individuals
Alegre et al., J Immunol 1998 : Inhibition of binding of CTLA-4 to its ligands using soluble anti-CTLA-4 mAb during stimulation with Ag increased the production not only of IL-2 by Th1 clones, but also that of IL-3 and IFN-gamma by Th1 clones and of IL-3, IL-4, IL-5 , and IL-10 by Th2 clones