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CTNNB1 — PRKAR1B

Text-mined interactions from Literome

Hino et al., Mol Cell Biol 2005 : Prostaglandin E ( 1 ) ( PGE ( 1 ) ), isoproterenol, and dibutyryl cAMP ( Bt ( 2 ) cAMP ), all of which activate PKA, increased the cytoplasmic and nuclear beta-catenin protein level, and these actions were suppressed by a PKA inhibitor and RNA interference for PKA ... Although PKA did not affect the formation of a complex between glycogen synthase kinase 3beta ( GSK-3beta ), beta-catenin, and Axin, phosphorylation of beta-catenin by PKA inhibited ubiquitination of beta-catenin in intact cells and in vitro ... Ser675 was found to be a site for phosphorylation by PKA, and substitution of this serine residue with alanine in beta-catenin attenuated inhibition of the ubiquitination of beta-catenin by PKA, PKA induced stabilization of beta-catenin , and PKA dependent activation of Tcf
Taurin et al., J Biol Chem 2006 : In the present study, we have shown that ( i ) beta-catenin can be phosphorylated by protein kinase A (PKA) in vitro and in intact cells at two novel sites, Ser-552 and Ser-675 ; ( ii ) phosphorylation by PKA promotes the transcriptional activity ( TCF/LEF transactivation ) of beta-catenin ; ( iii ) mutation of Ser-675 attenuates the promoting effect of PKA ; ( iv ) phosphorylation by PKA does not affect the GSK3 dependent phosphorylation of beta-catenin , its stability, or intracellular localization ; and ( v ) phosphorylation at the Ser-675 site promotes the binding of beta-catenin to its transcriptional coactivator, CREB binding protein
Tobimatsu et al., Endocrinology 2006 : The PKA activator, forskolin, and the PKC activator, phorbol 12-myristate-13-acetate, as well as the PTH analog, [ Nle ( 8,18 ), Tyr ( 34 ) ] human PTH- ( 3-34 ) amide, all increased beta-catenin levels ... In conclusion, the data demonstrate that PTH stimulates osteoblast beta-catenin levels via Smad3, and that both PKA and PKC pathways are involved
Taurin et al., Am J Physiol Cell Physiol 2008 : In the present study, using the phosphospecific antibodies against phospho-Ser552 or phospho-Ser675 sites of beta-catenin, we show that ATP can stimulate PKA dependent phosphorylation of endogenous beta-catenin at both of these sites without affecting its expression levels in VSMC
Sun et al., Theoretical biology & medical modelling 2009 : It has also been found that the kinase PKA attenuates beta-catenin degradation
Xia et al., Mol Cell Biol 2010 : Interestingly, the activation of PI3K/Akt appeared to be independent of the activation of PKA, whereas both PI3K/Akt and PKA signaling inactivated GSK-3 and increased beta-catenin translocation
Guo et al., Cell Metab 2010 : In cultured MC3T3E1 preosteoblastic cells, PTH dramatically suppressed Dkk1 expression, induced PKA mediated phosphorylation of beta-catenin , and significantly enhanced Lef1 expression