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AKT2 — CUL1

Text-mined interactions from Literome

Blume-Jensen et al., Nat Genet 2000 : The mutation completely disrupted PI 3'-kinase binding to Kit/SCF-R and reduced SCF induced PI 3'-kinase dependent activation of Akt by 90 %
Krystal et al., Clin Cancer Res 2000 (Carcinoma, Small Cell...) : STI571 efficiently blocked SCF mediated activation of mitogen activated protein kinase and Akt , but did not affect insulin-like growth factor-1 or serum mediated mitogen activated protein kinase or Akt activation
Bayle et al., J Biol Chem 2004 : SOCS6 reduced SCF induced activation of ERK1/2 and p38 but not activation of AKT or STATs in Ba/F3, murine embryonic fibroblast (MEF), or COS-7 cells
Möller et al., Blood 2005 : SCF induced a rapid and transient phosphorylation of Akt ( protein kinase B ) and FOXO3a
Dang et al., J Neurosci Res 2005 (Neurofibromatoses) : Although the c-Kit ligand stem cell factor (SCF) induces the phosphorylation of protein kinase B ( or Akt ) and prevents apoptosis in Schwann cells, SCF has no effect on the proliferation or differentiation of Schwann cells
Zeuner et al., Cancer Res 2007 (Thrombocytopenia) : In chemotherapy treated megakaryocytes, SCF activated Akt , neutralized the mitochondrial apoptotic machinery, and inhibited caspase activity
Suyama et al., Oncol Rep 2010 (Lung Neoplasms...) : Using c-kit positive SCLC cells ( H209 and H69 cells ) and SCF as a model of the autocrine mechanisms, the effects of SCF , LY294002, PD98059 or STI571 on Akt and Erk were assessed by Western blot analysis
Feuser et al., Mol Immunol 2011 : The combined challenge of mast cells with IL-4, SCF and Fc?RI cross linking substantially up-regulated activation of Akt , whereas blocking of Akt inhibited the pronounced production and release of IL-8 in response to the three mast cell agonists