Gene interactions and pathways from curated databases and text-mining

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CX3CR1 — IL6

Text-mined interactions from Literome

Lee et al., Eur J Pain 2010 : Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK ... Here, we investigated whether IL-6 regulates CX3CR1 expression through p38 MAPK activation in the spinal cord in rats with chronic constriction injury ( CCI ) of the sciatic nerve ... The increases in CX3CR1 expression, p38 MAPK activation and pain behavior after CCI were suppressed by blocking IL-6 action with a neutralizing antibody, while they were enhanced by supplying exogenous recombinant rat IL-6 ( rrIL-6 ) ... These results suggest a new mechanism of neuropathic pain, in which IL-6 induces microglial CX3CR1 expression in the spinal cord through p38 MAPK activation, enhancing the responsiveness of microglia to fractalkine in the spinal cord, thus playing an important role in neuropathic pain after peripheral nerve injury
Xiong et al., J Immunol 2011 (Pulmonary Emphysema) : Rather, functional CX3CR1 was required for a subset of tissue bound mononuclear phagocytes to produce TNF-a and IL-6 in response to cigarette smoke, and the absence of functional CX3CR1 protected mice from developing tissue-destructive emphysema
Butoi et al., Biochim Biophys Acta 2011 : Silencing the p65 ( NF-kB subunit ) inhibited the IL-1ß and IL-6 and silencing c-jun inhibited the TNFa, CX3CR1 and MMP-9 induced by SMC-monocyte interaction