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CYP4A11 — NOS2

Text-mined interactions from Literome

Tunctan et al., Nitric Oxide 2006 (Hypotension) : These data suggest that the endotoxemia induced increase in NO production primarily via iNOS suppresses renal CYP 4A expression and activity, and inhibition of iNOS with 1,3-PBIT restores renal CYP 4A protein and activity and MAP presumably due to increased production of arachidonic acid metabolites derived from CYP 4A
Tunctan et al., Arch Pharm Res 2008 (Hypotension...) : We have previously demonstrated that endotoxemia induced increase in NO production suppresses renal cytochrome P450 (CYP) 4A expression and activity, and that selective inhibition of inducible NO synthase (iNOS) with 1,3-PBIT restores renal CYP 4A protein and activity and mean arterial pressure ( MAP ) ... These data suggest that prostaglandins produced during endotoxemia increase iNOS protein expression and NO synthesis, and decrease CYP 4A protein expression and CYP 4A activity and that inhibition of iNOS or COX restores renal CYP 4A protein level and CYP 4A activity and MAP presumably due to increased production of arachidonic acid metabolites derived from CYP 4A
Tunctan et al., Prostaglandins Other Lipid Mediat 2013 (Endotoxemia...) : These data suggest that COX-2 derived vasodilator prostanoids, PGI2 and PGE2, produced during endotoxemia increase iNOS protein expression and activity as well as peroxynitrite formation resulting in decreased CYP4A1 protein expression and 20-HETE synthesis